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Metabolic Reactions: Role of Cytochrome P-450 in the Formation of Reactive Oxygen Species

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Cytochrome P450

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 105))

Abstract

The term “reactive oxygen” in reference to biological systems is not clearly defined. In this chapter it will be used in the sense of chemically activated oxygen, representing oxygen metabolites, mainly reduction products of oxygen, released from the cytochrome P-450 enzyme system. Reactive oxygen formed during the metabolic reaction of the cytochrome P-450 enzyme at the active site of the heme moiety will not be discussed here; the reader is referred to other chapters in this book.

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Authors
  1. H. Kappus
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Editors and Affiliations

  1. Department of Pharmacology, MC 1505, University of Connecticut Health Center, 263 Farmington Avenue, 06030, Farmington, CT, USA

    John B. Schenkman Ph.D.

  2. Institut für Toxikologie, Gesellschaft für Strahlen- und Umweltforschung mbH, Ingolstädter Landstr. 1, W-8042, Neuherberg, Fed. Rep. of Germany

    Helmut Greim M.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Kappus, H. (1993). Metabolic Reactions: Role of Cytochrome P-450 in the Formation of Reactive Oxygen Species. In: Schenkman, J.B., Greim, H. (eds) Cytochrome P450. Handbook of Experimental Pharmacology, vol 105. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77763-9_9

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  • DOI: https://doi.org/10.1007/978-3-642-77763-9_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77765-3

  • Online ISBN: 978-3-642-77763-9

  • eBook Packages: Springer Book Archive

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