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Metabolic Reactions: Mechanisms of Substrate Oxygenation

  • Chapter
Cytochrome P450

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 105))

Abstract

A characteristic property of cytochrome P450 enzymes is their ability to react with a multitude of chemically very different substrates. Despite this fact, the basic mechanism of substrate oxygenation is the same for multiple forms and isozymes; it includes the energy-expensive process of molecular oxygen activation, splitting and formation of a very reactive oxygen species suited to oxidizing such chemically inert compounds as alkanes. The catalytic power of cytochrome P450 can be demonstrated by the thermodynamic parameters of the oxygenation process (Eq. 1).

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Authors
  1. H. Rein
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  2. C. Jung
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Editors and Affiliations

  1. Department of Pharmacology, MC 1505, University of Connecticut Health Center, 263 Farmington Avenue, 06030, Farmington, CT, USA

    John B. Schenkman Ph.D.

  2. Institut für Toxikologie, Gesellschaft für Strahlen- und Umweltforschung mbH, Ingolstädter Landstr. 1, W-8042, Neuherberg, Fed. Rep. of Germany

    Helmut Greim M.D.

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Rein, H., Jung, C. (1993). Metabolic Reactions: Mechanisms of Substrate Oxygenation. In: Schenkman, J.B., Greim, H. (eds) Cytochrome P450. Handbook of Experimental Pharmacology, vol 105. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77763-9_7

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  • DOI: https://doi.org/10.1007/978-3-642-77763-9_7

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  • Print ISBN: 978-3-642-77765-3

  • Online ISBN: 978-3-642-77763-9

  • eBook Packages: Springer Book Archive

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