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Physiological Functions of Opioids:Temperature Regulation

  • Chapter
Opioids II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 104 / 2))

Abstract

Opiates and opioids have long been known to produce changes in body temperature. As with a wide variety of drugs from many different classes of pharmacological agents, the specific effect on body temperature is dependent on a number of factors such as the dose and route of administration of the drug, the species, strain, and age of animal, ambient temperature, and circadian rhythms. In addition, the degree of the restraint of the animal can alter the effects of opioids on body temperature. These and other factors have been addressed in a number of reviews and some will be mentioned below. Although less is known about the actions of opioids other than morphine on body temperature, there is increasing evidence that the endogenous opioid system (ligands and receptors) plays a role in thermoregulation in many animal species. This chapter will review much of this evidence and discuss ideas as to the function of specific receptor types based on our current knowledge.

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Authors
  1. M. W. Adler
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  2. E. B. Geller
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Editors and Affiliations

  1. Abteilung Neuropharmakologie, Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18, W-8033, Martinsried, Germany

    Albert Herz

  2. Mental Health Research Institute, School of Medicine, University of Michigan, 205 Zina Pitcher, 48109, Ann Arbor, MI, USA

    Huda Akil

  3. Medical Center, School of Medicine, New York University, 550 First Avenue, 10016, New York, NY, USA

    Eric J. Simon

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Adler, M.W., Geller, E.B. (1993). Physiological Functions of Opioids:Temperature Regulation. In: Herz, A., Akil, H., Simon, E.J. (eds) Opioids II. Handbook of Experimental Pharmacology, vol 104 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77540-6_9

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  • DOI: https://doi.org/10.1007/978-3-642-77540-6_9

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