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Role of leukotrienes B4 and C4 in liver allograft rejection

  • Conference paper
Transplant International Official Journal of the European Society for Organ Transplantation

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Abstract

Previous studies have shown that eicosanoids may act in vitro as immunoregulatory substances. In this study, the concentrations of leukotriene B4 (LTB4) and leukotriene C4 (LTC4) were measured in a model of allograft rejection. Six orthotopic allotransplants of the liver were performed in dogs without the administration of immunosuppressives. LTB4 levels showed an increase coinciding with the start of rejection, significant differences being present between the basal levels and those measured 24 h post-revascularization (P<0.05), and every day from the 3rd postoperative day (P < 0.01). LTB4 rose before the parameters generally used in evaluating rejection. LTC4 levels increased significantly (P< 0.001) in the first 24 h, and experienced no further variations. LTB4 may play an important role in the mechanisms which bring about the response to the allograft. This substance could be a specific and early marker for rejection.

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Authors and Affiliations

  1. Departments of Surgery, Medicine and Pathology, Clínica Universitaria, University of Navarra, Navarra, Spain

    J. González, J. A. Cienfuegos, E. Pardo, J. Sola, J. L. Hernández, C. Rodríguez-Ortigosa, C. Benito, E. Balén, F. J. Pardo & J. Quiroga

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  1. J. González
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  2. J. A. Cienfuegos
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  3. E. Pardo
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  4. J. Sola
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  5. J. L. Hernández
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  6. C. Rodríguez-Ortigosa
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  7. C. Benito
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  8. E. Balén
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  9. F. J. Pardo
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  10. J. Quiroga
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Editor information

Editors and Affiliations

  1. Department of Surgery, University Hospital, P.O.Box 5800, 6202 AZ, Maastricht, The Netherlands

    Gauke Kootstra

  2. Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, W-6900, Heidelberg, Germany

    Gerhard Opelz

  3. Department of Surgery, University of Limburg, (B. M. C.) Beeldsnijderdreef 101, NL-6216 EA, Maastricht, The Netherlands

    W. A. Buurman

  4. Department of Nephrology, University Hospital Maastricht, P. Debyelaan 25, NL-6202 AZ, Maastricht, The Netherlands

    J. P. van Hooff

  5. The Liver Unit, Queen Elizabeth Hospital, B152TH, Edgbaston, Birmingham, UK

    P. MacMaster

  6. Papworth Hospital, CB3 8RE, Papworth Everard, Cambridgeshire, UK

    J. Wallwork

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© 1992 Springer-Verlag Berlin Heidelberg

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González, J. et al. (1992). Role of leukotrienes B4 and C4 in liver allograft rejection. In: Kootstra, G., Opelz, G., Buurman, W.A., van Hooff, J.P., MacMaster, P., Wallwork, J. (eds) Transplant International Official Journal of the European Society for Organ Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77423-2_193

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  • DOI: https://doi.org/10.1007/978-3-642-77423-2_193

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55342-7

  • Online ISBN: 978-3-642-77423-2

  • eBook Packages: Springer Book Archive

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