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Prolongation of heart allograft survival in rats by interferon-specific antibodies and low dose cyclosporin A

  • Conference paper
Transplant International Official Journal of the European Society for Organ Transplantation

Abstract

Interferons (IFNs) are important cytokines which exhibit antiviral, antitumor, anticellular, as well as immunoregulatory activities [1]. Among these multiple activities, IFNs are potent inducers of MHC antigen expression of a great variety of cells [2–4], helper and maturation factors in B-cell antibody production [5], and macrophage function [6]. IFNs may therefore play a critical role in triggering antigen recognition and allograft rejection.

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© 1992 Springer-Verlag Berlin Heidelberg

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Gugenheim, J. et al. (1992). Prolongation of heart allograft survival in rats by interferon-specific antibodies and low dose cyclosporin A. In: Kootstra, G., Opelz, G., Buurman, W.A., van Hooff, J.P., MacMaster, P., Wallwork, J. (eds) Transplant International Official Journal of the European Society for Organ Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77423-2_134

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  • DOI: https://doi.org/10.1007/978-3-642-77423-2_134

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55342-7

  • Online ISBN: 978-3-642-77423-2

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