Abstract
A multicentre study of ABO incompatible kidney transplantation using Biosynsorb was started in Japan in November 1989. A total of 51 cases were registered comprising 23 cases of A incompatibility, 26 cases of B incompatibility and two cases of AB incompatibility. The removal of antibodies (IgG and IgM) was carried out using Biosynsorb in 16 cases, plasmapheresis in four cases and use of both combined in 31 cases. The treatment using Biosynsorb was repeated 3.4 times on average. Serum ti-tres of anti-A (IgG and IgM) antibodies decreased to 4.9 ± 5.0 and 2.7 ± 1.7 and for anti-B titres decreased to 2.8 ± 3.5 and 2.4 ± 3.2. Rejection was found in 33 cases: hyperacute one, accelerated acute five, and acute 27. In two cases rejection was developed concomitantly with a steep elevation in antibody titres. Three patients died, two with functioning grafts. Eight grafts were lost. Patient and graft survivals at 2years were 94.1% and 84.3%, respectively. From these results it is concluded that: 1. Biosynsorb and plasmapheresis are effective in removing anti-A and anti-B antibodies; 2. graft and patient survivals are similar to those in ABO compatible cases; 3. anti-A and anti-B titres less than 16 are recommended at the time of transplantation; 4. anti-A and anti-B titres higher than 128 may be considered as a risk factor for rejection in the early stages after transplantation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Agishi T, Kaneko I, Hasuo Y, Hayasaka Y, Sanaka T, Ota K (1980) Double filtration plasmapheresis. Trans Am Soc Artif Intern Organs 26:406–411
Alexandre GPJ, Squifflet JP, Bruyere MD, Latinne R, Reding R, Gianello P, Carlier M, Pirson Y (1987) Present experiences in a series of 26 ABO-incompatible living donor renal allografts. Transplant Proc 19:4538–4542
Bannett AD, McAlack RF, Raja R, Baquero A, Morris M (1987) Experiences with known ABO-mismatched renal transplants. Transplant Proc 19:4543–4546
Bensinger WI, Baker DA, Buckner CD, Clift RA, Thomas ED (1981) Immunoadsorption for removal of A and B blood-group antibodies. N Engl J Med 304:160–162
Chopek MW, Simmons RL, Piatt JL (1987) ABO-incompatible kidney transplantation: initial immunopathologic evaluation. Transplant Proc 19:4553–4557
McAlack RF, Bannett AD, Raja R, Kim P, Romano E, Lauzon G (1987) Delayed hyperacute rejection in an ABO-incompatible renal transplant. Transplant Proc 19:4558–1560
Merrill JP, Murray JE, Harrison JH, Guild WG (1956) Successful homotransplantation of the human kidney between identical twins. JAMA 160:277–282
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Ota, K. et al. (1992). Multicentre trial of ABO-incompatible kidney transplantation. In: Kootstra, G., Opelz, G., Buurman, W.A., van Hooff, J.P., MacMaster, P., Wallwork, J. (eds) Transplant International Official Journal of the European Society for Organ Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77423-2_13
Download citation
DOI: https://doi.org/10.1007/978-3-642-77423-2_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-55342-7
Online ISBN: 978-3-642-77423-2
eBook Packages: Springer Book Archive