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Alterations in Function and Phenotype of Monocytes from Patients with Septic Disease: Predictive Value and New Therapeutic Strategies

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Host Defense Dysfunction in Trauma, Shock and Sepsis

Abstract

Recently we described the usefulness of immune monitoring as a guide for immunosuppression in allograft recipients with septic complications [1]. From cytofluorometric analyses of mononuclear cells (MNC), the HLA-DR antigen expression on monocytes seems to be the most important diagnostic parameter for the clinical management of immunosuppressed patients with sepsis. A restitution of diminished HLA-DR antigen expression on monocytes after rapid decline of immunosuppression was associated with a favorable outcome of sepsis [1]. Further studies on surgical patients suffering from septic disease (peritonitis as septic focus) not receiving therapeutically induced immunosuppression confirmed the predictive value of HLA-DR antigen expression on monocytes for clinical outcome [2, 3]. Taking a proportion of HLA-DR+ monocytes lower than 20% as the threshold for predicting fatal outcome, we correctly classified survivors and nonsurvivors in all but one case (n = 38) between the 5th and 7th days after admission to the ICU.

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Authors and Affiliations

  1. Institute For Medical Immunology, Charité, Humboldt-Universität Berlin, Schumannstr. 20/21, 1040, Berlin, Germany

    H. D. Volk, M. Thieme, U. Ruppe, S. Heym, W. D. Döcke & R. van Baehr

  2. Clinic For Surger, Charité, Humboldt-Universität Berlin, Schumannstr. 20/21, 1040, Berlin, Germany

    M. Thieme, U. Ruppe, D. Manger & S. Zuckermann

  3. Clinic For Intensive Care, Charité, Humboldt-Universität Berlin, Schumannstr. 20/21, 1040, Berlin, Germany

    A. Golosubow & H. Klug

  4. Clinic For Internal Medicine, Charité, Humboldt-Universität Berlin, Schumannstr. 20/21, 1040, Berlin, Germany

    B. Nieter

Authors
  1. H. D. Volk
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  2. M. Thieme
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  3. U. Ruppe
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  4. S. Heym
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  5. W. D. Döcke
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  6. D. Manger
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  7. S. Zuckermann
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  8. A. Golosubow
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  9. B. Nieter
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  10. H. Klug
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  11. R. van Baehr
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Editor information

Editors and Affiliations

  1. Dept. of Surgery, Ludwig-Maximilians-University Munich, Klinikum Großhadern Marchioninistr. 15, 8000, Munich 70, Germany

    Eugen Faist  & Friedrich W. Schildberg  & 

  2. Dept. of Surgery, McGill University, Room 510.34 687 Pine Avenue West, Montreal, Quebec, H3A 1A1, Canada

    Jonathan L. Meakins M.D., D.Sc.

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© 1993 Springer-Verlag, Berlin Heidelberg

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Volk, H.D. et al. (1993). Alterations in Function and Phenotype of Monocytes from Patients with Septic Disease: Predictive Value and New Therapeutic Strategies. In: Faist, E., Meakins, J.L., Schildberg, F.W. (eds) Host Defense Dysfunction in Trauma, Shock and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77405-8_40

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  • DOI: https://doi.org/10.1007/978-3-642-77405-8_40

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77407-2

  • Online ISBN: 978-3-642-77405-8

  • eBook Packages: Springer Book Archive

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