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Mechanosensitive Ion Channels in Yeast. Mechanisms of Activation and Adaptation

  • Chapter
Comparative Aspects of Mechanoreceptor Systems

Part of the book series: Advances in Comparative and Environmental Physiology ((COMPARATIVE,volume 10))

Abstract

The ability to sense and respond to mechanical stresses in the environment is almost certainly a universal feature of all cells. Although there are specialized cells (e.g., hair cells in the cochlea) for sensing mechanical stimuli, many if not all cells appear capable of detecting changes in pressure on their cell membrane. The mechanosensors for most mechanical stimuli appear to reside in the cell surface membrane. Physiological experiments have demonstrated that the activity of certain ion channels (mechanosensitive channels; Howard et al. 1988; Sachs 1989; Morris 1990), solute transporters (Wood 1988), and enzymes (Watson 1990) is regulated by mechanical stress on the cell membrane. The molecular mechanism of how mechanical stress activates such membrane proteins remains a complete mystery.

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Authors and Affiliations

  1. Department of Biochemistry and Cell Biology, Rice University, 77251, Houston, TX, USA

    M. C. Gustin

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  1. M. C. Gustin
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Editors and Affiliations

  1. Department of Physiology School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan

    Fumio Ito

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Gustin, M.C. (1992). Mechanosensitive Ion Channels in Yeast. Mechanisms of Activation and Adaptation. In: Ito, F. (eds) Comparative Aspects of Mechanoreceptor Systems. Advances in Comparative and Environmental Physiology, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76690-9_2

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  • DOI: https://doi.org/10.1007/978-3-642-76690-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76692-3

  • Online ISBN: 978-3-642-76690-9

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