Abstract
As a background for this discussion on the biology of multiple myeloma (MM) I will make a few remarks about the pathogenesis of the disease and the role of interleukin-6 (IL-6) as a growth factor for MM cells. I will finally argue that, since IL-6 stimulates the growth of MM cells by a paracrine rather than an autocrine mechanism, knowledge about the regulation of the IL-6 production in the non-MM bone-marrow cells may be relevant for epidemiological studies on MM.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Akira S, Isshiki H, Sugita T, Tanabe O, Kinoshita S, Nishio Y, Nakajima T, Hirano T, Kishimoto T (1990) A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP-family. EMBO J 9:1897–1906.
Andersson K C, Jones R M, Morimoto C, Leavitt P, Barut B A (1989) Response patterns of purified myeloma cells to hematopoietic growth factors. Blood 73:1915–1924.
Brenning G (1985) The in vitro effect of leukocyte-a interferon on human myeloma cells in a semisolid agar culture system. Scand J Haematol 35:178–185.
Dewald G W, Kyle R A, Hicks G A, Greipp P R (1985) The clinical significance of cytogenetic studies in 100 patients with multiple myeloma. Plasma cell leukemia, or amyloidosis. Blood 66:380–390.
Gould J, Alexanian R, Goodacre A, Pathak S, Hecht B, Barlogie B (1988) Plasma cell karyotype in multiple myeloma. Blood 71:453–456.
Jernberg H, Zech L, Nilsson K (1987) Cytogenetic studies on human myeloma cell lines. Int J Cancer 40:811–817.
Jirik F R, Podor T J, Hirano T, Kishimoto T, Loskutoff D J, Carson D A, Lots M (1989) Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J Immunol 142:144– 147.
Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe O, Tanaka H, Kuramoto A, Kishimoto T (1988) Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 332:83–85.
Kishimoto T (1989) The biology of interleukin-6. Blood 74:1–10.
Klein B, Jourdan M, Vazques A, Dugas B, Bataille R (1987) Production of growth factors by human myeloma cells. Cancer Res 47:4856–4860..
Klein B, Zhang X-G, Jourdan M, Content J, Houssiau F, Aarden L, Piechaczyk M, Bataille R (1989) Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood 73:517–526.
Lewis J P, MacKenzie M R (1984) Non-random chromosomal aberrations associated with multiple myeloma. Hematol Oncol 2:307–317.
Liang W, Hopper J E, Rowley J D (1979) Karyotypic abnormalities and clinical aspects of patients with multiple myeloma and related paraproteinemic disorders. Cancer 44:630–644.
Nemunaitis J, Andres D F, Mochizuki D Y, Lilly M B, Singer J W (1989) Human marrow stromal cells: Response to interleukin-6 (IL-6) and control of IL-6 expression. Blood 74:1929–1935.
Neri A, Murphy J P, Cro L, Ferrero D, Tarella C, Baldini L, Dalla-Favera R (1989) ras oncogene mutation in multiple myeloma. J Exp Med 170:1715–1725.
Nilsson K (1989) IN: F Melchers, M Potter (eds.) Mechanisms of B cell neoplasia. Editiones Roche, Basel, Switzerland, pp 229–235.
Nilsson K, Jernberg H, Pettersson M (1990) IL-6 as a growth factor for human multiple myeloma cells -a short overview. IN: F Melchers, M Potter (eds.) Current Topics of Microbiology and Immunology. Springer Verlag Berlin-Heidelberg-New York-London-Paris-Tokyo, in press.
Philip P (1980) Chromosomes of monoclonal gammopathies. Cancer Genet Cytogenet 2:79–86.
Selvanayagam P, Blick M, Narni F, van Tuinen P, Ledbetter D H, Alexanian R, Saunders G F, Barlogie B (1988) Alteration and abnormal expression of the c-myc oncogene in human multiple myeloma. Blood 71:30–35.
Shimizu S, Yoshioka R, Hirose Y, Sugai S, Tachibana J, Konda S (1989) Establishment of two interleukin 6 (B cell stimulatory factor 2/interferon ß2)-dependent human bone marrow-derived myeloma cell lines. J Exp Med 169:339–344.
Tanabe O, Kawano M, Tanaka H, Iwato K, Asaoku H, Ishikawa H, Nobuyoshi M, Hirano T, Kishimoto T, Kuramoto A (1989) BSF-2/IL-6 does not augment Ig secretion but stimulates proliferation in myeloma cells. Am J Hematol 31:258–262.
Van Damme J, Schaafsma M R, Fibbe W E, Falkenburg J H F, Opdenakker G, Billiau A (1989) Simultaneous production of interleukin 6, interferon-ß and colony-stimulating activity by fibroblasts after viral and bacterial infection. Eur J Immunol 19:163–168.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Nilsson, K. (1991). Open Discussion on the Biology of Multiple Myeloma. Chairman’s Introductory Remarks. In: Obrams, G.I., Potter, M. (eds) Epidemiology and Biology of Multiple Myeloma. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76655-8_19
Download citation
DOI: https://doi.org/10.1007/978-3-642-76655-8_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-76657-2
Online ISBN: 978-3-642-76655-8
eBook Packages: Springer Book Archive