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Sequential Analysis of P-Glycoprotein Expression in Childhood Acute Lymphoblastic Leukemia

  • Conference paper
Acute Leukemias

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 34))

Abstract

Tumor-cell resistance to cytotoxic drugs is thought to be a major cause of failure in the chemotherapy of malignant tumors. One type identified as multidrug resistance (MDR) in experimental systems including human tumor cell lines was first described in 1970 in Chinese hamster lung and P388 leukemia cells [1]. Resistant tumor cells exhibit decreased sensitivity, not only to the initial drug used to promote resistance but also to a variety of structurally diverse molecules to which they have not been previously exposed (reviewed in [21]). At the molecular level, such resistant cells have been found to exhibit increased expression of P-glycoprotein (P-gp), a 170-kDa trans-membrane glycoprotein encoded by the MDR1 gene. The functionally relevant characteristic of MDR cells is a defective intracellular accumulation of cytotoxic drugs due to the overexpression of P-gp, which acts as an energy-dependent efflux pump for the transfer of cytotoxic drugs to the external medium.

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Author information

Authors and Affiliations

  1. Department of Hematology/Oncology, Klinikum Steglitz, Berlin, Germany

    D. Kingreen, C. Sperling, M. Notter, E. Thiel & W.-D. Ludwig

  2. Department of Internal Medicine, University Hospital R. Virchow, Berlin, Germany

    C. Schmidt

  3. Medical Laser Center, Lübeck, Germany

    H. Diddens

  4. Department of Pediatrics, Hannover Medical School, Hannover, Germany

    H. Riehm

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  1. D. Kingreen
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  2. C. Sperling
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  6. H. Riehm
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  7. E. Thiel
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Editors and Affiliations

  1. Department of Internal Medicine, University of Münster, Albert-Schweitzer-Straße 33, D-4400, Münster, Federal Republic of Germany

    W. Hiddemann , T. Büchner  & B. Wörmann ,  & 

  2. M. D. Anderson Cancer Center, University of Texas, 1515 Holocombe Boulevard, 77030, Houston, TX, USA

    W. Plunkett , M. Keating  & M. Andreeff ,  & 

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© 1992 Springer-Verlag Berlin Heidelberg

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Kingreen, D. et al. (1992). Sequential Analysis of P-Glycoprotein Expression in Childhood Acute Lymphoblastic Leukemia. In: Hiddemann, W., Büchner, T., Wörmann, B., Plunkett, W., Keating, M., Andreeff, M. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76591-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-76591-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53949-0

  • Online ISBN: 978-3-642-76591-9

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