Abstract
Aberrations of the long arm of chromosome 5 (5q) are recurrent chromosomal anomalies in (secondary) acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) [1]. Common clinical features of these patients are poor response to cytostatic therapy and shorter survival time in comparison to patients with other cytogenetic abnormalities. In a recent evaluation of AML and MDS patients a critical region consisting of bands 5q23–32 was identified. These findings led to the hypothesis that the genes encoding for growth factors and growth factor receptors (e.g., GM-CSF, M-CSF, IL3, CSF-1-rec. = CD14) located within this region play an important role in the pathogenesis of these diseases [2]. Several authors described loss of heterozygosity of these genes [3–6], and Cheng et al. [7] detected structural alterations of the GMCSF gene in two cases of AML that could not be found in remission.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Nimer SD, Golde DW (1987) The 5q-abnormality. Blood 70: 1705
Le Beau MM, Albain KS, Larson R, Vardiman JW, Davies EM, Blough RR, Golomb HM, Rowley JD (1986) Clinical and cytogenetic correlations in 63 patients with therapy related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosome no.5 and 7. J Clin Oncol 4: 325
Huebner K, Isobe M, Croce CM, Golde DW, Kaufmann SE, Gasson JC (1985) The human gene encoding GM-CSF is at 5q21-q32, the chromosome region deleted in the 5q-anomaly. Science 230: 1282
Le Beau MM, Pettenati MJ, Lemons RS, Diaz MO, Westbrook CA, Larson RA, Sherr CJ, Rowley JD (1986) Assignment of the GM-CSF, CSF-1, and fms genes to human chromosome 5 provides evidence for linkage of a family of genes regulating hematopoiesis and for their involvement in the deletion (5q) in myeloid disorders. Cold Spring Harb Symp Quant Biol 51: 899
Pettenati MJ, Le Beau MM, Lemons RS, Shima EA, Kawasaki ES, Larson RA, Sherr CJ, Diaz MO, Rowley JD (1987) Assignment of CSF-1 to 5q33.1: evidence fora clustering of genes regulating hematopoiesis and for their involvement in the deletion of the long arm of chromosome 5 in myeloid disorders. Proc Natl Acad Sci USA 84: 2970
Nienhuis AW, Bunn HF, Turner PH, Gopal TV Nash WG, O’Brien SJ, Sherr CJ (1985) Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in. the 5q-syndrome. Cell 42: 421
Cheng GYM, Kelleher CA, Miyauchi J, Wong G, Clark SC, McCulloch EA, Minden MD (1988) Structure and expression of genes of GM-CSF and G-CSF in blast cells from patients with acute myeloblastic leukemia. Blood 71: 204–208
Schweizer D (1981) Counterstain enhanced chromosome banding. Hum Genet 57: 307
Harden DG, Klinger HP (eds) (1985) ISCN: An international system for human cytogenetic nomenclature. Birth defects Original article series, 21/1. March of Dimes Birth Defect Foundation, New York
Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human uncleated cells Nucleic Acids Res 61 (3): 1215
Goyert SM, Ferrero E, Rettio WJ, Yenamandra AK, Obata F, Le Beau MM (1988) The CD 14 monocyte differentation antigen maps to a region encoding growth factors and receptors. Science 239: 497
Nagarajan L, Lange B, Cannizzaro L„ Finan J, Nowell PC, Huebner K (1990) Molecular anatomy of a 5q interstitial deletion. Blood 75: 82
Bodmer NF, Bailly CJ, Bodmer J, Bussey HVR, Ellis A, Gorman P, Lucibello FC, Murday VA, Rider SH, Scambler P, Sheer D, Solomon E, Spurr NK (1987) Localisation of the gene for familial adenomatous polyposis on chromosome 5 (1987) Nature 328, 614
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Weber, E., Karlic, H., Krieger, O., Grill, R., Lutz, D. (1992). GM-CSF, CD14, and C-fms Genes in 12 Patients with 5q Abnormalities. In: Hiddemann, W., Büchner, T., Wörmann, B., Plunkett, W., Keating, M., Andreeff, M. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76591-9_36
Download citation
DOI: https://doi.org/10.1007/978-3-642-76591-9_36
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-53949-0
Online ISBN: 978-3-642-76591-9
eBook Packages: Springer Book Archive