Abstract
Cholecystokinin (CCK) is the most potent hormonal stimulus for contraction of the gallbladder [1–3] thereby markedly increasing the delivery of bile acids into the duodenum. Together with monoglycerides and phospholipids, bile acids form mixed micelles to facilitate fat absorption. Eventually, 95% of them are reabsorbed by the terminal ileum to finish the enterohepatic cycle [4]. Since bile acids presumably get in contact with intestinal CCK cells and are closely linked to the digestion and absorption of fat, a potent stimulus for CCK secretion, there is likely a relationship between bile acids and CCK release.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Maton PN, Seiden AC, Fitzpatrick ML, Chadwick VS (1984) Infusion of cholecystokinin octapeptide in man: relation between plasma cholecystokinin concentrations and gallbladder emptying rates. Eur J Clin Invest 14:37–41
Anagnostides AA, Chadwick VS, Seiden AC, Barr J, Maton PN (1985) Human pancreatic and biliary responses to physiological concentrations of cholecystokinin octapeptide. Clin Sci 69:259–263
Niederau C, Heintges T, Rovati L, Strohmeyer G (1989) Effects of loxiglumide in gallbladder emptying in healthy volunteers. Gastroenterology 97:1331–1336
Erlinger S (1987) Physiology of bile secretion and enterohepatic circulation. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven, New York, pp 1557–1580
Gomez G, Lluis F, Guo YS, Greeley GH, Townsend CM, Thompson JC (1986) Bile inhibits release of cholecystokinin and neurotensin. Surgery 100:363–367
Koop I, Dorn S, Koop H, Witzleb S, Beglinger C, Schafmayer A, Arnold R (1990) Dissociation of cholecystokinin and pancreatico-biliary response to intraduodenal bile acids and cholestyramine in humans. Dig Dis Sci (in press)
Gomez G, Upp JR, Lluis F, Alexander RW, Poston GJ, Greeley GH, Thompson JC (1988) Regulation of the release of cholecystokinin by bile salts in dogs and humans. Gastroenterology 94:1036–1046
Koop I, Koop H, Gerhardt C, Schafmayer A, Arnold R (1989) Do bile acids exert a negative feedback control on cholecystokinin release? Scand J Gastroenterol 24:315–320
Gomez G, Townsend CM, Maani R, Singh P, Greeley G, Thompson JC (1989) Down-regulation of pancreatic growth and gallbladder contractility by bile salts. Am J Surg 157:20–26
Nakamura R, Miyasaka K, Kuyama Y, Kitani K (1990) Luminal bile regulates cholecystokinin release in conscious rats. Dig Dis Sci 35:55–60
Hagerman LM, Julow DA, Schneider DL (1973) In vitro binding of mixed micellar solutions of fatty acids and bile salts by cholestyramine. Proc Soc Exp Biol Med 143:89–92
Koop I, Fellgiebel A, Koop H, Schafmayer A, Arnold A (1988) Effect of cholestyramine on plasma cholecystokinin and pancreatic polypeptide levels and exocrine pancreatic secretion. Eur J Clin Invest 18:517–523
Nordstroem C (1972) Release of enteropeptidase and other brush-border enzymes from the small intestinal wall in the rat. Biochim Biophys Acta 289: 367–377
Götze H, Adelson JW, Hadorn HB, Portmann R, Troesch V (1972) Hormone-elicited enzyme release by the small intestinal wall. Gut 13:471–476
Green G, Nasset ES (1977) Effect of bile duct obstruction on pancreatic enzyme secretion and intestinal proteolytic enzyme activity in rats. Dig Dis Sci 22: 437–444
Green G, Nasset ES (1980) Importance of bile in regulation of intraluminal proteolytic enzyme activities in the rat. Gastroenterology 79:695–702
Miysaka K, Nakamura R, Funakoshi A, Kitani K (1989) Stimulatory effect of monitor peptide and human pancreatic secretory inhibitor on pancreatic secretion and cholecystokinin release in conscious rats. Pancreas 4:139–144
Iwai K, Fushiki T, Fukuoka S (1988) Pancreatic enzyme secretion mediated by novel peptide: monitor peptide hypothesis. Pancreas 3:720–728
Koop I, Lindenthal M, Schade T, Adler G, Arnold R (1991) Role of cholecystokinin in cholestyramine-induced changes of the exocrine pancreas. Pancreas (in press)
Baba N, Suzuki T, Tobe T, Inoue K, Chowdhury P, Change L, Rayford P (1986) Influence of obstructive jaundice on pancreatic growth and on basal plasma levels of cholecystokinin and gastrin in rats. Dig Dis Sci 31:1233–1241
Green G, Levan VH, Liddle RA (1986) Plasma cholecystokinin and pancreatic growth during adaptation to dietary protein. Am J Physiol 251:G70–G74
Koop I, Witzleb S, Adler G, Nustede R, Arnold R (1990) Effect of cholecystokinin (CCK) receptor blockade on bile acid-induced changes in CCK, neurotensin and pancreatic enzyme release. Gastroenterology 98:A222
Brand SJ, Morgan RGH (1982) Stimulation of pancreatic secretion and growth in the rat after feeding cholestyramine. Gastroenterology 83:851–859
Malagelada JR, Go VLW, DiMagno EP (1973) Interactions between intraluminal bile acids and digestive products on pancreatic and gallbladder function. J Clin Invest 52:2160–2165
Malagelada JR, DiMagno EP, Summerskill WHJ, Go VLW (1976) Regulation of pancreatic and gallbladder functions by intraluminal fatty acids and bile acids in man. J Clin Invest 58:493–499
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Koop, I. (1991). Regulation of CCK Release by Bile Acids. In: Adler, G., Beglinger, C. (eds) Cholecystokinin Antagonists in Gastroenterology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76362-5_15
Download citation
DOI: https://doi.org/10.1007/978-3-642-76362-5_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-76364-9
Online ISBN: 978-3-642-76362-5
eBook Packages: Springer Book Archive