Abstract
During the last two decades several brain imaging techniques have been introduced into psychiatric research allowing the study of various aspects of brain function and structure in relation to disease and treatment. Of these, positron emission tomography (PET) is the most powerful. In PET, radioactive tracers make it possible to study regional biochemistry and neuroreceptors in the living human brain. So far most PET studies in schizophrenia have dealt with regional glucose metabolism and have increased our knowledge of brain function in this severe disease. A new field of application to psychiatric research is the study of neuroreceptor characteristics and thus of mechanisms of action of psychotropic drugs.
This study was supplied by grants from the Swedish Medical Research Council (07027, 08318), The Bank of Sweden Tercentenary Fondation and the US National Institute of Mental Health.
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Aquilonius SM, Bergström K, Eckernäs SÅ, Hartvig P, Leenders KL, Lundquist H, Antoni G, Gee A, Rimland A, Uhlin J, Långström B (1987) In vivo evaluation of striatal dopamine reuptake sites using 11C-nomifensine and positron emission tomography. Acta Neurol Scand 76:283–287
Blin J, Pappata S, Kiyosawa M, Crouzel C, Baron JC (1988) (18F)Setoperone: a new high-affinity ligand for positron emission tomography study of the serotonin-2 receptors in baboon brain in vivo. Eur J Pharmacol 147:73–82
Blomqvist G, Bergström K, Bergström M, Ehrin E, Eriksson L, Garmelius B, Lindberg B, Lilja A, Litton J-E, Lundmark L, Lundqvist H, Malmborg P, Moström U, Nilsson L, Stone-Elander S, Widén L (1985) Models for 11C-glucose. In: Greitz T, Ingvar DH, Widén L (eds) The metabolism of the human brain studied with positron emission tomography. Raven, New York, pp 185–194
Blomqvist G, Stone-Elander S, Halldin C, Roland PE, Widén L, Lindqvist M, Swahn C-G, Långström B, Wiesel F-A (1990) Positron emission tomographic measurements of cerebral glucose utilization using (1-11C)-D-glucose. J Cereb Blood Flow Metab 10:467–483
Borg J, Edström L, Bjerkenstedt L, Wiesel F-A, Farde L, Hagenfeldt L (1987) Muscle biopsy findings, conduction velocity and refractory period of single motor nerve fibres in schizophrenia. J Neurol Neurosurg Psychiatry 50:1655–1664
Buchsbaum MS, Ingvar DH, Kessler R, Waters RN, Cappelletti J, van Kammen DP, King AC, Johnson JL, Manning RG, Flynn RW, Mann LS, Bunney WE, Sokoloff L (1982) Cerebral glucography with positron tomography. Arch Gen Psychiatry 39:251–259
Buchsbaum MS, DeLisi LE, Holcomb HH, Cappelletti J, King AC, Johnson J, Hazlett E, Drowling-Zimmerman S, Post RM, Morihisa J, Carpenter W, Cohen R, Pickar D, Weinberger DR, Margolin R, Kessler R (1984) Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders. Arch Gen Psychiatry 41:1159–1165
Buchsbaum MS, Wu JC, DeLisi LE, Holcomb HH, Hazlett E, Cooper-Langston K, Kessler R (1987) Positron emission tomography studies of basal ganglia and somatosensory cortex neuroleptic drug effects: Differences between normal controls and schizophrenic patients. Biol Psychiatry 22:479–494
Cambon H, Baron JC, Boulenger JP, Loc’h C, Zarifian E, Maziere B (1987) In vivo assay for neuroleptic receptor binding in the striatum. Positron tomography in humans. Br J Psychiatry 151:824–830
Cohen RM, Semple WE, Gross M, Nordahl TE, DeLisi LE, Holcomb HH, Kind AC, Morihisa JM, Picar D (1987) Dysfunction in a prefrontal substrate of sustained attention in schizophrenia. Life Sci 40:2031–2039
Crawley JCW, Crow TJ, Johnstone EC, Oldland SRD, Woen F, Owens DGC, Smith T, Veall N, Zanelli GD (1986) Uptaker of 77Br-spiperone in the striata of schizophrenic patients and controls. Nucl Med Commun 7:599–607
DeLisi LE, Buchsbaum MS, Holcomb HH, Dowling-Zimmerman S, Pickar D, Boronow J, Morihisa JM, van Kammen DP, Carpenter W, Kessler R, Cohen RM (1985) Clinical correlates of decreased anteroposterior metabolic gradients in positron emission tomography (PET) of schizophrenic patients. Am J Psychiatry 142:78–81
Early TS, Reiman EM, Raichle ME, Spitznagel EL (1987) Left globus pallidus abnormality in never-medicated patients with schizophrenia. Proc Natl Acad Sci USA 84:561–563
Farde L, Hall H, Ehrin E, Sedvall G (1986) Quantitative analysis of D2-dopamine receptor binding in the living human brain by PET. Science 231:258–261
Farde L, Halldin C, Stone-Elander S, Sedvall G (1987a) PET analysis of human dopamine receptor subtypes using 11C-SCH 23390 and 11C-raclopride. Psychopharmacology (Berlin) 92:278–284
Farde L, Wiesel FA, Hall H, Halldin C, Stone-Elander S, Sedvall G (1987b) No D2-receptor increase in PET study of schizophrenia. Arch Gen Psychiatry 44:671–672
Farde L, Pauli S, Hall H, Eriksson L, Halldin C, Högberg T, Nilsson L, Sjögren I, Stone-Elander S (1988a) Stereoselective binding of 11C-raclopride in living human brain — a search for extrastriatal central D2-dopamine receptors by PET. Psychopharmacology (Berlin) 94:471–478
Farde L, Wiesel FA, Halldin C, Sedvall G (1988b) Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs. Arch Gen Psychiatry 45:71–76
Farde L, Wiesel FA, Nordstrom AL, Sedvall G (1989b) PET examination of human D1- and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics. Psychopharmacology (Berlin) 99:528–531
Farde L, Wiesel FA, Halldin C, Stone-Elander S, Nordstrom A-L (1990) D2-dopamine receptor characteristics in neuroleptic-naive patients with schizophrenia. Arch Gen Psychiatry 47:213–219
Farkas T, Wolf AP, Jaeger J, Brodie JD, Christman DR, Fowler JS (1984) Regional brain glucose metabolism in chronic schizophrenia. Arch Gen Psychiatry 41:293–300
Fox PT, Raichle ME, Thach WT (1985) Functional mapping of the human cerebellum with positron emission tomography. Proc Natl Acad Sci USA 82:7462–7466
Fox PT, Raichle ME, Mintun MA, Dence C (1988) Nonoxidative glucose consumption during focal physiologic neural activity. Science 241:462–464
Frost JJ, Mayberg HS, Fisher RS, Douglass KH, Dannals RF, Links JM, Wilson AA, Ravert HT, Rosenbaum AE, Snyder SH, Wagner HN (1988) Mu-opiate receptors measured by positron emission tomography are increased in temporal lobe epilepsy. Ann Neurol 23:231–237
Garnett ES, Nahmias C, Firnau G (1984) Central dopaminergic pathways in hemiparkinsonism examined by positron emission tomography. Can J Neurol Sci 11:174–179
Geraud G, Arne-Bes MC, Guell A, Bes A (1987) Reversibility of hemodynamic hypofrontality in schizophrenia. J Cereb Blood Flow Metab 7:9–12
Goode DJ, Meltzer HY, Crayton JW, Mazura TA (1977) Physiologic abnormalities of the neuromuscular system in schizophrenia. Schizophr Bull 3:121–138
Gur RE, Resnick SM, Alavi A, Gur RC, Caroff S, Dann R, Silver FL, Saykin AJ, Chawluk JB, Kushner M, Reivich M (1987) Regional brain function in schizophrenia. Arch Gen Psychiatry 44:119–125
Hagenfeldt L, Venizelos N, Bjerkenstedt L, Wiesel FA (1987) Decreased tyrosine transport in fibroblasts from schizophrenic patients. Life Sci 41:2749–2757
Holman BL, Gison RE, Hill TC, Eckelman WC, Albert M, Reba RC (1985) Muscarinic acetylcholine receptors in Alzheimer’s disease. In vivo imaging with iodine 123-labelled 3-quinuclidinyl-4-iodobenzilate and emission tomography. JAMA 254:3063–3066
Huang SC, Barrio JR, Phelps ME (1986) Neuroreceptor assay with positron emission tomography: equilibrium versus dynamic approaches. J Cereb Blood Flow Metab 6:515–521
Ingvar DH, Franzén G (1974) Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr Scand 50:425–462
Jernigan TL, Sargent T III, Pfefferbaum A, Kusubov N, Stahl SM (1985) 18Fluorodeoxyglucose PET in schizophrenia. Psychiatry Res 16:317–329
Kane J, Honigfeld G, Singer J, Meltzer H (1988) Clozapine for the treatment-resistant schizophrenic. Arch Gen Psychiatry 45:789–796
Kling AS, Metter EJ, Riege WH, Kuhl DE (1986) Comparison of PET measurement of local brain glucose metabolism and CAT measurement of brain atrophy in chronic schizophrenia and depression. Am J Psychiatry 143:175–180
Mackay AVP, Iversen LL, Rossor M, Spokes E, Bird E, Arregui A, Creese I, Snyder SH (1982) Increased brain dopamine and dopamine receptors in schizophrenia. Arch Gen Psychiatry 39:991–997
Mazière B, Loc’h C, Hantraye P, Stulzaft O, Martinot JL, Syrota A, Mazière M (1988) PET imaging of D2 receptors in the living baboon or human brain in normal and pathological conditions using 76Br-bromolisuride. Psychopharmacology [Suppl] (Berlin) 96:19
Mazziotta JC, Phelps ME, Plummer D, Kuhl DE (1981) Quantitation in positron emission computed tomography. 5. Physical-anatomical effects. J Comput Assist Tomogr 5:734–743
Nybäck H, Nordberg A, Långström B, Halldin C, Hartvig P, Âhlin A, Sedvall G (1989) Attempts to visualize nicotinic receptors in the brain of monkey and man by positron emission tomography. In: Progress in brain research, vol 9. Elsevier Science, Amsterdam, pp 313–319
Persson A, Pauli S, Halldin C, Stone-Elander S, Farde L, Sjögren I, Sedvall G (1989) Saturation analysis of specific 11C Ro 15-1788 binding to the human neocortex using positron emission tomography. Hum Psychopharmacol 4:21–31
Phelps ME, Huang SC, Hoffman EJ, Selin C, Sokoloff L, Kuhl DE (1979) Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method. Ann Neurol 6:371–388
Raichle ME (1980) Cerebral blood flow and metabolism in man: past, present and future. Trends Neurosci 3:VI-X
Raichle ME, Mintun MA, Herscovitch P (1985) Positron emission tomography with 15oxygen radiopharmaceuticals. In: Sokoloff L (ed) Brain imaging and brain function. Raven, New York, pp 51–59
Reivich M, Alavi A, Wolf A, Fowler J, Russell J, Arnett C, MacGregor RR, Shiue CY, Atkins H, Anand A, Dann R, Greenberg JH (1985) Glucose metabolic rate kinetic model parameter determination in humans: the lumped constants and rate constants for (18F)fluorodeoxyglucose and (11C)deoxyglucose. J Cereb Blood Flow Metab 5:179–192
Resnick SM, Gur RE, Alavi A, Gur RC, Reivich M (1988) Positron emission tomography and subcortical glucose metabolism in schizophrenia. Psychiatry Res 24:1–11
Seeman P, Ulpian C, Bergeron C, Riederer P, Jellinger K, Gabriel E, Reynolds GP, Tourtellotte WW (1984) Bimodal distribution of dopamine receptor densities in brains of schizophrenics. Science 225:728–731
Sheppard G, Manchanda R, Gruzelier J, Hirsch SR (1983) 15O positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients. Lancet 2:1448–1452
Smith M, Wolf AP, Brodie JD, Arnett CD, Barouche F, Shiue C-Y, Fowler JS, Russell JAG, MacGregor RR, Wolkin A, Angrist B, Rotrosen J, Peselow E (1988) Serial (18F)N-methylspiroperidol PET studies to measure changes in antipsychotic drug D-2 receptor occupancy in schizophrenic patients. Biol Psychiatry 23:653–663
Sokoloff L (1985) Basic principles in imaging of regional cerebral metabolic rates. In: Sokoloff L (ed) Brain imaging and brain function. Raven, New York, pp 21–49
Swart JA, Korf J (1987) In vivo dopamine receptor assessment for clinical studies using positron emission tomography. Biochem Pharmacol 36:2241–2250
Szechtman H, Nahmias C, Garnett ES, Firnau G, Brown GM, Kaplan RD, Cleghom JM (1988) Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia. Arch Gen Psychiatry 45:523–532
Ter-Pogossian MM, Raichle ME, Sobel BE (1980) Positron-emission tomography. Sci AM 243:170–181
Volkow ND, Brodie JD, Wolf AP, Gomez-Mont F, Cancro R, van Gelder P, Rusell JAG, Overall J (1986) Brain organization in schizophrenia. Cereb Blood Flow Metab 6:441–446
Volkow ND, Wolf AP, van Gelder P, Brodie JD, Overall JE, Cancro R, Gomez-Mont F (1987) Phenomenological correlates of metabolic activity in 18 patients with chronic schizophrenia. Am J Psychiatry 144:151–158
Walker MD (ed) (1984) Research issues in positron emission tomography. Ann Neurol [Suppl] 15
Wiesel FA, Blomqvist G, Ehrin E, Greitz T, Ingvar DH, Litton J, Nilsson L, Sedvall G, Stone-Elander S, Widén L, Wik G (1985) Brain energy metabolism in schizophrenia studied with 11C-glucose. In: Greitz T, Ingvar DH, Widén L (eds) The metabolism of the human brain studied with positron emission tomography. Raven, New York, pp 485–493
Wiesel FA, Wik G, Sjögren I, Blomqvist G, Greitz T (1987a) Altered relationships between metabolic rates of glucose in brain regions of schizophrenic patients. Acta psychiatr Scand 76:642–647
Wiesel FA, Wik G, Sjögren G, Blomqvist G, Greitz T, Stone-Elander S (1987b) Regional brain glucose metabolism in drug free schizophrenic patients and clinical correlates. Acta Psychiatr Scand 76:628–641
Wiesel F-A, Halldin C, Blomqvist G, Sjögren I, Stone-Elander S, Bjerkenstedt L, Hagenfeldt L, Venizelos N (1989) The influx of tyrosine across the blood brain barrier in healthy volunteers and schizophrenic patients. J Cereb Blood Flow Metab [Suppl] 9:565
Wolkin A, Jaeger J, Brodie JD, Wolf AP, Fowler J, Rotrosen J, Gomez-Mont F, Cancro R (1985) Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography. Am J Psychiatry 142:564–571
Wolkin A, Angrist B, Wolf A, Brodie JD, Wolkon RN, Jaeger J, Cancro R, Rotrosen J (1988) Low frontal glucose utilization in chronic schizophrenia: a replication study. Am J Psychiatry 145:251–253
Wong DF (1988) Strategies for in vivo quantification of human neuroreceptors by PET, Psychopharmacology [Suppl] (Berlin) 96:18
Wong DF, Gjedde A, Wagner HN (1986a) Quantification of neuroreceptors in the living human brain. I. Irreversible binding of ligands. J Cereb Blood Flow Metab 6:137–146
Wong DF, Gjedde A, Wagner HN, Dannais RF, Douglass KH, Links JM, Kuhar MJ (1986b) Quantification of neuroreceptors in the living human brain. II. Inhibition studies of receptor density and affinity. J Cereb Blood Flow Metab 6:147–153
Wong DF, Wagner HN, Tune LE, Dannais RF, Pearlson GD, Links JM, Tamminga CA, Broussole EP, Ravert HT, Wilson AA, Toung JKT, Malat J, Williams JA, O’Tuama LA, Snyder SH, Kuhar MJ, Gjedde A (1986c) Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science 234:1558–1563
Wong DF, Lever JR, Hartig PR, Dannais RF, Villemagne V, Hoffman BJ, Wilson AA, Ravert HT, Links JM, Scheffel U, Wagner HN Jr (1987) Localization of serotonin 5-HT2receptors in living human brain by positron emission tomography using Nl-(11C-Methyl)-2-B-LSD. Synapse 1:393–398
Yarowski PJ, Ingvar PH (1981) Neuronal activity and energy metabolism. Fed Proc 40:2353–3262
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Wiesel, FA., Farde, L., Nordström, AL., Sedvall, G., Wik, G. (1990). Positron Emission Tomography in Schizophrenia. In: Häfner, H., Gattaz, W.F. (eds) Search for the Causes of Schizophrenia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74881-3_22
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DOI: https://doi.org/10.1007/978-3-642-74881-3_22
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