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Inflammation and Repair

  • Chapter
Peptide Growth Factors and Their Receptors II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 95 / 2))

Abstract

Injuries to tissue, whether due to mechanical, chemical, immunological, or thermal insults, initiate an orderly but complex series of cellular and biochemical interactions that lead to the formation of new tissue and the eventual repair of the wound. The cellular components of this pathway include hematopoietic cells such as platelets, polymorphonuclear leukocytes, lymphocytes, and monocytes, and mesenchymal cells such as fibroblasts and endothelial cells. These cells migrate to the site of tissue damage in a sequence determined by soluble factors that are released at the site of injury through a wide variety of mechanisms. Among these are tissue breakdown, blood coagulation, and cellular release. Each cell type has a specific function to perform such as degradation and resorption of damaged tissue, protection against infection, or deposition of new extracellular matrix.

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  1. H. L. Wong
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Editors and Affiliations

  1. Laboratory of Chemoprevention, National Cancer Institute, 20892, Bethesda, MD, USA

    Michael B. Sporn M. D.  & Anita B. Roberts Ph. D.  & 

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Wong, H.L., Wahl, S.M. (1990). Inflammation and Repair. In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors II. Handbook of Experimental Pharmacology, vol 95 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74781-6_18

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  • DOI: https://doi.org/10.1007/978-3-642-74781-6_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74783-0

  • Online ISBN: 978-3-642-74781-6

  • eBook Packages: Springer Book Archive

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