Abstract
The results of chemotherapy in adults with acute lymphoblastic leukemia (ALL) have improved in recent years but have lagged behind those in children with ALL [1, 2]. The overall probability of achieving complete remission (CR) exceeds 75%, and it now appears that approximately 35% of patients achieving CR can be cured using chemotherapy alone [2, 3]. It is therefore appropriate to study alternative forms of treatment such as allogeneic or autologous bone marrow transplantation (BMT) in adult ALL.
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Clarkson B, Ellis S, Little C, Gee T, Arlin Z, Mertelsmann R, Andreeff M, Kempin S, Koziner B, Chaganti R, Jhanwars S, Mc Kenzie S, Cirrincione G, Gaynor J (1985) Acute lymphoblastic leukemia in adults. Semin Oncol 12: 160–179
Hoelzer D, Thiel E, Loffler H, Büchner T, Ganser A, Heil G, Koch P, Freund M, Diedrich H, Ruhl H, Maschmeyer G, Lipp T, Nowrousian MR, Burkert M, Gerecke D, Pralle H, Muller U, Lunschken C, Fülle H, Ho AD, Kuchler R, Busch FW, Schneider W, Gorg C, Emmerich B, Braumann D, Vaupel HA, van Paleske A, Bartels H, Neiss A, Messerer D (1988) Prognostic factors in a multicenter study for treatment of acute lymphoblastic leukemia in adults. Blood 71: 123–131
Gaynor J, Chapman D, Little C, Mc Kenzie S, Miller W, Andreeff M, Arlin Z, Berman E, Kempin S, Gee T, Clarkson B (1988) A cause specific hazard rate analysis of prognostic factors among 199 adults with acute lymphoblastic leukemia. The Memorial Hospital experience since 1969. J Clin Oncol 6: 1014–1030
Fiere D, Extra JM, David B, Witz F, Vernant JP, Gastaut JA, Dauriac C, Pris J, Marty M (1987) Treatment of 218 adult acute lymphoblastic leukemia. Semin Oncol 14: 64–66
Blomfield CD, Goldman AI, Alimena G, Berger R, Borgstrom GH, Brandt L, Catovsky D, de la Chapelle A, Dewald GW, Garson OM, Garwicz S, Golomb HM, Hossfeld DK, Lawler SD, Mitelman F, Nilsson P, Pierre RV, Philip P, Prigogina E, Rowley JD, Sakurai M, Sandberg A A, Seeker Walker LM, Tricot G, van den Berghe H, van Orshoven A, Vuopio P, Whang Peng J (1986) Chromosomal abnormalities identify highrisk and low-risk patients with acute lymphoblastic leukemia. Blood 67: 412–420
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (FAB Cooperative Group) (1976) Proposals for the classification of the acute leukaemias. Br J Haematol 33: 451–458
Doney K, Buckner CD, Kopecky KJ (1987) Marrow transplantation for patients with acute lymphoblastic leukemia in first marrow remission. Bone Marrow Transplant 72: 355–363
Blume KG, Forman SJ, Snyder DS, Nadamarree AP, O’Donnel MR, Fahey JC, Krance RA, Smecinski IJ, Stock AD, Findley DO, Lipsett JA, Schmidt GM, Nathwani MB, Hill CR, Metter GE (1987) Allogenic bone marrow transplantation for acute lymphoblastic leukemia during first complete remission. Transplantation 43: 389–392
Gorin NC, Aergerter P, Auvert B (1988) Autologous bone marrow transplantation (ABMT) for acute leukemia in remission: fifth European survey. Evidence in favor of marrow purging. Influence of pre transplant intervals. Bone Marrow Transplant 3 (1): 39–41
Gale RP, Champlin RE (1986) Bone marrow transplantation in acute leukaemia. Clin Haematol 15: 851
Gale RP (1989) ALL. Comparison of IBMTR results with chemotherapy and auto-transplants. In: 2nd Int Symp acute leukemias. Prognostic factors and treatment strategies, Münster, 19–22 Feb. 1989 (Abstr no 149)
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Fiere, D. et al. (1990). Comparison of Chemotherapy and Autologous and Allogeneic Transplantation as Postinduction Regimen in Adult Acute Lymphoblastic Leukemia: a Preliminary Multicentric Study. In: Büchner, T., Schellong, G., Hiddemann, W., Ritter, J. (eds) Acute Leukemias II. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74643-7_76
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DOI: https://doi.org/10.1007/978-3-642-74643-7_76
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