Abstract
Several of the major complications of blood transfusion result from white cell contamination of blood components, such as nonhemolytic febrile reactions, refractoriness to platelet transfusion, and virus transmission [1, 2, 5, 7]. There is evidence that mainly lymphocyte-contaminated blood products are the major cause of alloimmunizationand refractoriness of the recipients [3, 6]. Repeated transfusion of platelet concentrates leads to HLA alloimmunization in 40% of patients [3]. The management of alloimmunized patients represents a difficult and expensive challenge and any means by which the rate of alloimmunization can be reduced is to be welcomed. Therefore, blood component therapy aims to transfuse standardized blood products as purely as possible in a very selective way in order to provide optimal therapeutic efficacy and minimal side effects.
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© 1990 Springer-Verlag Berlin Heidelberg
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Müller, N., Gummelt, M., Osskop, S., Schlake, C. (1990). Lymphocyte Contamination in Leukocyte-Depleted Red Cell and Platelet Concentrates Obtained by Filtration. In: Büchner, T., Schellong, G., Hiddemann, W., Ritter, J. (eds) Acute Leukemias II. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74643-7_102
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DOI: https://doi.org/10.1007/978-3-642-74643-7_102
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