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Mechanisms in Myeloid Tumorigenesis 1988 pp 45–57Cite as

Recombinant Inbred Mouse Strains: Models for Studying the Molecular Genetic Basis of Myeloid Tumorigenesis

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 149))

Abstract

Several inbred mouse strains have been derived that have a high spontaneous incidence of hematopoietic disease (reviewed by Gross 1983). Invariably, the high tumor incidence in these strains is causally associated with the expression of murine leukemia viruses (MuLV). Viruses expressed by these strains are inherited vertically, as normal Mendelian genes, or horizontally via infection of newborns through the mothers milk or of embryos, in utero. These viruses do not transform cells in culture and they do not carry oncogenes. They induce disease only after long latency periods, apparently by insertional activation of cellular genes (reviewed by Nusse, 1986).

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References

  • Baumbach WR, Stanley ER, Cole MD (1987) Induction of clonal monocyte-macrophage tumors in vivo by a mouse c-myc retrovirus: Rearrangement of the CSF-1 gene as a secondary transforming event. Mol Cell Biol 7: 664–671

    PubMed  CAS  Google Scholar 

  • Bedigian HG, Johnson DA, Jenkins NA, Copeland NG, Evans R (1984) Spontaneous and induced leukemias of myeloid origin in recombinant inbred BXH mice. J Virol 51: 586–594

    PubMed  CAS  Google Scholar 

  • Bedigian HG, Taylor BA, Meier H (1981) Expression of murine leukemia viruses in the highly lymphomatous BXH-2 recombinant inbred mouse strain. J Virol 39: 632–640

    PubMed  CAS  Google Scholar 

  • Bordereaux D, Fichelson S, Sola B, Tambourin PE, Gisselbrecht S (1987) Frequent involvement of the fim-3 region in Friend murine leukemia virus-induced mouse myeloblastic leukemias. J Virol 61: 4043–4045

    PubMed  CAS  Google Scholar 

  • Buchberg AM, Bedigian HG, Taylor BA, Brownell E, Ihle JN, Nagata S, Jenkins NA, Copeland NG (1988) Localization of Evi-2 to chromosome 11: Linkage to other proto-oncogene and growth factor loci using interspecific backcross mice. Oncogene Res 2: 149–165

    PubMed  CAS  Google Scholar 

  • Copeland NG, Jenkins NA, Nexo B, Schultz AM, Rein A, Mikkelsen T, Jorgensen P (1988) Poorly expressed endogenous ecotropic provirus of DBA/2 mice encodes a mutant Pr659a9 protein that is not myristylated. J Virol 62: 479–487

    PubMed  CAS  Google Scholar 

  • Corcoran LM, Adams JM, Dunn AR, Cory S (1984) Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion. Cell 37: 113–122

    Article  PubMed  CAS  Google Scholar 

  • Cuypers HT, Selten G, Quint W, Zijlstra M, Maandag ER, Boelens W, van Wezenbeek P, Melief C, Berns A (1984) Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region. Cell 37: 141–150

    Article  PubMed  CAS  Google Scholar 

  • George DL, Glick B, Trusko S, Freeman N (1986) Enhanced c-Ki-ras expression associated with Friend virus integration in a bone marrow-derived mouse cell line. Proc Natl Acad Sci USA 83: 1651–1655

    Article  PubMed  CAS  Google Scholar 

  • Gisselbrecht S, Fichelson S, Sola B, Bordereaux D, Hampe A, Andre C, Galibert F, Tambourin P (1987) Frequent c-fms activation by proviral insertion in mouse myeloblastic leukemias. Nature 329: 259–261

    Article  PubMed  CAS  Google Scholar 

  • Graham M, Adams JM, Cory S (1985) Murine T lymphomas with retroviral inserts in the chromosomal 15 locus for plasmacytoma variant translocations. Nature 314: 740–743

    Article  PubMed  CAS  Google Scholar 

  • Gross L (1983) In: Oncogenic Viruses, Vol 1 (3rd edition) Pergamon Press, Inc., Elmsford, New York

    Google Scholar 

  • Hanecak R, Pattengale PK, Fan H (1988) Addition or substitution of simian virus 40 enhancer sequences into the Moloney murine leukemia virus (M-MuLV) long terminal repeat yields infectious M-MuLV with altered biological properties. J Virol 62: 2427–2436

    PubMed  CAS  Google Scholar 

  • Hartley JW, Wolford NK, Old LJ, Rowe WP (1977) A new class of murine leukemia virus associated with development of spontaneous lymphomas. Proc Natl Acad Sci USA 74: 789–792

    Article  PubMed  CAS  Google Scholar 

  • Herr W, Gilbert W (1983) Somatically acquired recombinant murine leukemia proviruses in thymic leukemias of AKR/J mice. J Virol 46: 70–82

    PubMed  CAS  Google Scholar 

  • Herr W, Gilbert W (1984) Free and integrated recombinant murine leukemia virus DNAs appear in preleukemic thymuses of AKR/J mice. J Virol 50: 155–162

    PubMed  CAS  Google Scholar 

  • Holland CA, Hartley JW, Rowe WP, Hopkins N (1985) At least four viral genes contribute to the 1eukemogenicity of murine retrovirus MCF 247 in AKR mice. J Virol 53: 158–165

    PubMed  CAS  Google Scholar 

  • Jenkins NA, Copeland NG, Taylor BA, Bedigian HG, Lee BK (1982a) Ecotropic murine leukemia virus DNA content of normal and lymphomatous tissues of BXH-2 recombinant inbred mice. J Virol 42: 379–388

    PubMed  CAS  Google Scholar 

  • Jenkins NA, Copeland NG, Taylor BA, Lee BK (1982b) Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J Virol 43: 26–36

    PubMed  CAS  Google Scholar 

  • Li Y, Holland CA, Hartley JW, Hopkins N (1984) Viral integrations near c-myc in 10–20% of MCF 247-induced AKR lymphomas. Proc Natl Acad Sci USA 81: 6808–6811

    Article  PubMed  CAS  Google Scholar 

  • Marth JD, Peet R, Krebs EG, Perlmutter RM (1985) A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell 43: 393–404

    Article  PubMed  CAS  Google Scholar 

  • Moreau-Gachelin F, Tavitian A, Tambourin P (1988) Spi-1 is a putative oncogene in virally induced murine erythroleukaemias. Nature 331: 277–280

    Article  PubMed  CAS  Google Scholar 

  • Mucenski ML, Gilbert DJ, Taylor BA, Jenkins NA, Copeland NG (1987a) Common sites of viral integration in lymphomas arising in AKXD recombinant inbred mouse strains. Oncogene Res 2: 33–48

    PubMed  CAS  Google Scholar 

  • Mucenski ML, Taylor BA, Copeland NG, Jenkins NA (1987b) Characterization of somatically acquired ecotropic and mink cell focus-forming viruses in lymphomas of AKXD recombinant inbred mice. J Virol 61: 2929–2933

    PubMed  CAS  Google Scholar 

  • Mucenski ML, Taylor BA, Copeland NG, Jenkins NA (1988a) Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors. Oncogene Res 2: 219–233

    PubMed  CAS  Google Scholar 

  • Mucenski ML, Taylor BA, Ihle JN, Hartley JW, Morse HC III, Jenkins NA, Copeland NG (1988b) Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors. Mol Cell Biol 8: 301–308

    PubMed  CAS  Google Scholar 

  • Mucenski ML, Taylor BA, Jenkins NA, Copeland NG (1986) AKXD recombinant inbred strains: models for studying the molecular genetic basis of murine lymphomas. Mol Cell Biol 6: 4236–4243

    PubMed  CAS  Google Scholar 

  • Mushinski JF, Potter M, Bauer SR, Reddy EP (1983) DNA rearrangement and altered RNA expression of the c-myb oncogene in mouse plasmacytoid lymphosarcomas. Science 220: 795–798

    Article  PubMed  CAS  Google Scholar 

  • Nusse R (1986) The activation of cellular oncogenes by retroviral insertion. Trends in Genet 2: 244–247

    Article  CAS  Google Scholar 

  • Quint W, Boelens W, van Wezenbeek P, Cuypers T, Maandag ER, Selten G, Berns A (1984) Generation of AKR mink cell focus-forming viruses: A conserved single copy xenotropic-1ike provirus provides recombinant long terminal repeat sequences. J Virol 50: 432–438

    PubMed  CAS  Google Scholar 

  • Reicin A, Yang J-Q, Marcu KB, Fleissner E, Koehne CF, O’Donnell PV (1986) Deregulation of the c-myc oncogene in virus-induced thymic lymphomas of AKR/J mice. Mol Cell Biol 6: 4088–4092

    PubMed  CAS  Google Scholar 

  • Rowley JD, Golomb HM, Dougherty C (1977a) 15/17 translocation, a consistent chromosomal change in acute promyelocytic leukemia. Lancet 1: 549–550

    Article  PubMed  CAS  Google Scholar 

  • Rowley JD, Golomb HM, Vardman J, Fukuhara S, Dougherty C, Potter D. (1977b) Further evidence for a non-random chromosomal abnormality in acute promyelocytic leukemia. Int J Cancer 20: 869–872

    Article  PubMed  CAS  Google Scholar 

  • Selten G, Cuypers HT, Berns A (1985) Proviral activation of the putative oncogene Pim-1 in MuLV-induced T-cell lymphomas. EMBO J 4: 1793–1798

    PubMed  CAS  Google Scholar 

  • Selten G, Cuypers HT, Boelens W, Robanus-Maandag E, Verbeek J, Domen J, van Beveren C, Berns A (1986) The primary structure of the putative oncogene Pim-1 shows extensive homology with protein kinases. Cell 46: 603–611

    Article  PubMed  CAS  Google Scholar 

  • Selten G, Cuypers HT, Zijlstra M, Melief C, Berns A (1984) Involvement of c-myc in MuLV-induced T cell lymphomas in mice: Frequency and mechanisms of activation. EMBO J 3: 3215–3222

    PubMed  CAS  Google Scholar 

  • Shen-Ong GLC, Morse HC III, Potter M, Mushinski JF (1986) Two modes of c-myb activation in virus-induced mouse myeloid tumors. Mol Cell Biol 6: 380–392.

    PubMed  CAS  Google Scholar 

  • Shen-Ong GLC, Potter M, Mushinski JF, Lavu S, Reddy EP (1984) Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas, Science 226: 1077–1080

    Article  PubMed  CAS  Google Scholar 

  • Silver J, Kozak C (1986) Common proviral integration region on mouse chromosome 7 in lymphomas and myelogenous leukemias induced by Friend murine leukemia virus. J Virol 57: 526–533.

    PubMed  CAS  Google Scholar 

  • Sola B, Fichelson S, Bordereaux D, Tambourin PE, Gisselbrecht S (1986) fim-1 and fim-2: Two new integration regions of Friend murine leukemia virus in myeloblastic leukemias. J Virol 60: 718–725

    PubMed  CAS  Google Scholar 

  • Taylor BA (1979) Recombinant inbred strains: Use in gene mapping. In: Morse HC III (ed) Origins of inbred mice. Academic Press, Inc., New York

    Google Scholar 

  • Villemur R, Monczak Y, Rassart E, Kozak C, Jolicoeur P (1987) Identification of a new common provirus integration site in Gross passage A murine leukemia virus-induced mouse thymoma DNA. Mol Cell Biol 7: 512–522

    PubMed  CAS  Google Scholar 

  • Voronova AF, Sefton BM (1986) Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion. Nature 319: 682–685

    Article  PubMed  CAS  Google Scholar 

  • Warren W, Lawley PD, Gardner E, Harris G, Ball JK, Cooper CS (1987) Induction of thymomas by N-methyl-N-nitrosourea in AKR mice: Interaction between the chemical carcinogen and endogenous murine leukemia viruses. Carcinogenesis 8: 163–172

    Article  PubMed  CAS  Google Scholar 

  • Weinstein Y, Ihle JN, Lavu S, Reddy EP (1986) Truncation of the c-myb gene by a retroviral integration in an interleukin 3-dependent myeloid leukemia cell line. Proc Natl Acad Sci USA 83:5010–5014

    Article  PubMed  CAS  Google Scholar 

  • Wirschubsky Z, Tschilis P, Klein G, Sumegi J (1986) Rearrangement of c-myc, Pim-1 and Nlvi-1 and trisomy of chromosome 15 in MCF-and Moloney-MuLV-induced murine T-cell leukemias. Int J Cancer 38: 739–745

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Mammalian Genetics Laboratory, BRI - Basic Research Program, NCI - Frederick Cancer Research Facility, Frederick, MD, 21701, USA

    Neal G. Copeland, Arthur M. Buchberg, Debra J. Gilbert & Nancy A. Jenkins

Authors
  1. Neal G. Copeland
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  2. Arthur M. Buchberg
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  3. Debra J. Gilbert
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  4. Nancy A. Jenkins
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Editor information

Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institutes, National Institutes of Health, Bethesda, MD, 20892, USA

    Grace L. C. Shen-Ong Ph. D.  & Michael Potter M. D.  & 

  2. Mammalia Genetics Laboratory, BRI - Basic Research Program, NCI - Frederick Cancer Research Facility, MD, 21701, USA

    Neal G. Copeland Ph. D.

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© 1989 Springer-Verlag Berlin · Heidelberg

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Copeland, N.G., Buchberg, A.M., Gilbert, D.J., Jenkins, N.A. (1989). Recombinant Inbred Mouse Strains: Models for Studying the Molecular Genetic Basis of Myeloid Tumorigenesis. In: Shen-Ong, G.L.C., Potter, M., Copeland, N.G. (eds) Mechanisms in Myeloid Tumorigenesis 1988. Current Topics in Microbiology and Immunology, vol 149. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74623-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-74623-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74625-3

  • Online ISBN: 978-3-642-74623-9

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