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Intracellular pH of Cardiac Cells: Hormonal Regulation and Role in Ischemia

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Adrenergic System and Ventricular Arrhythmias in Myocardial Infarction

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Abstract

It is important that the intracellular pH (pHi) of cardiac cells be maintained at a precise and defined value. This is because a change in pHi dramatically modifies myocardial contractility. As a rule, intracellular acidosis reduces myocardial contractility, whereas alkalosis produces a positive inotropic effect. These effects are fully reversible. The inotropic effects of changes in pHi are mainly due to a modified sensitivity of the myofilaments to Ca2+ [1]. In addition, altered pHi values in cardiac cells modify the diastolic level of intracellular Ca2+ [2, 3] and the magnitude of the Ca2+ transient that underlies contraction [4], possibly by modifying the release of Ca2+ from the sarcoplasmic reticulum [1,5]. Changes in extracellular pH also modify contractility, either in a direct way by modifying the electrical properties of the plasma membrane [6, 7] or in an indirect way by changing pHi.

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Authors
  1. C. Frelin
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  2. P. Vigne
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  3. M. Lazdunski
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Editors and Affiliations

  1. Abteilung für Innere Medizin III, Kardiologie Medizinische Universitätsklinik, Bergheimer Straße 58, 6900, Heidelberg 1, Germany

    J. Brachmann  & A. Schömig  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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Frelin, C., Vigne, P., Lazdunski, M. (1989). Intracellular pH of Cardiac Cells: Hormonal Regulation and Role in Ischemia. In: Brachmann, J., Schömig, A. (eds) Adrenergic System and Ventricular Arrhythmias in Myocardial Infarction. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74317-7_16

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  • DOI: https://doi.org/10.1007/978-3-642-74317-7_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74319-1

  • Online ISBN: 978-3-642-74317-7

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