Abstract
Menadione (2-methyl-1,4-naphthoquinone), a blood coagulant drug, is known to cause hemolysis and impaired liver function. We have investigated the metabolism of the drug and its effect on the hepatic uptake and biliary excretion of the bile acid taurocholate in the perfused rat liver.
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References
Akerboom TPM, Bultmann T, Sies H (1988) Inhibition of biliary taurocholate excretion during menadione metabolism in perfused rat liver. Arch Biochem Biophys 263: 10–18
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© 1989 Springer-Verlag Berlin Heidelberg
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Akerboom, T.P.M., Bultmann, T., Sies, H. (1989). Biliary Taurocholate Excretion During the Metabolism of 2-Methyl-1, 4-Naphthoquinone (Menadione) in Perfused Rat Liver. In: Petzinger, E., Kinne, R.K.H., Sies, H. (eds) Hepatic Transport of Organic Substances. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74247-7_30
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DOI: https://doi.org/10.1007/978-3-642-74247-7_30
Publisher Name: Springer, Berlin, Heidelberg
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