Abstract
The most important characteristic of malignant tumors is their tendency to infiltrate normal tissues and their ability to metastasize. Metastasis formation is a multistep process that probably requires a complex interplay of a large and heterogeneous group of genes, including genes involved in cellular resistance to immunorejection and genes controlling adhesion and invasive potential of cells. At present little is known about the genetic control of invasion and metastasis and the role of oncogenes in these processes. In our studies we have employed mouse BW5147 T lymphoma cells to analyze the genetic basis of invasion and metastasis of tumor cells by means of transfection experiments and somatic cell fusion studies.
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© 1989 Springer-Verlag Berlin Heidelberg
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Habets, G.G.M., Collard, J.G. (1989). Genetic Analysis of Invasive and Metastatic Capacity in T Lymphoma Cells. In: Schirrmacher, V., Schwartz-Albiez, R. (eds) Cancer Metastasis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74236-1_5
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DOI: https://doi.org/10.1007/978-3-642-74236-1_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-50471-9
Online ISBN: 978-3-642-74236-1
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