Abstract
The finding that potent preparations of mouse interferon a/ß inhibited the development of several viral-induced leukemias of mice, inhibited the growth of transplantable ascitic tumors, and markedly increased survival time (reviewed in Gresser 1977) prompted us to determine the effect of similar interferon preparations on the development of tumor metastases.
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References
Affabris E, Jemma C, Rossi GB (1982) Isolation of interferon-resistant variants of Friend erythroleukemia cells: effects of interferon and ouabain. Virology 120:441–452
Altevogt P, Fogel M, Cheingsong-Popov R, Dennis J, Robinson P, Schirrmacher V (1983) Different patterns of lectin binding and cell surface sialylation detected on related high-and low-metastatic tumor lines. Cancer Res 43:5138–5144
Amici C, Ferrantini M, Benedetto A, Belardelli F, Gresser I (1984) Biologic and biochemical differences between in vitro and in vivo passaged Friend erythroleukemia cells. II. Changes in cell surface glycoproteins associated with a highly malignant phenotype. Int J Cancer 34:397–402
Belardelli F, Ferrantini M, Maury C, Santurbano L, Gresser I (1984) Biologic and biochemical differences between in vitro and in vivo passaged Friend erythroleukemia cells. I. Tumorigenicity and capacity to metastasize. Int J Cancer 34:389–395
Belardelli F, Gresser I, Maury C, Duvillard P, Prade M, Maunoury MT (1983) Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. III. Inhibition of growth and necrosis of tumors implanted subcuta-neously. Int J Cancer 31:649–653
Benedetto A, Elia G, Sala A, Belardelli F (1988) Hyposialylation of high molecular weight membrane glycoproteins parallels the loss of metastatic potential in wheat germ agglutinin-resistant Friend leukemia cells. Int J Cancer (in press)
Brunda MJ, Rosenbaum D, Stern L (1984) Inhibition of experimentally-induced murine métastases by recombinant alpha interferon: correlation between the modulatory effect of interferon treatment on natural killer cell activity and inhibition of métastases. Int J Cancer 34:421–426
Dvorak HF, Gresser I, Microvascular injury in the pathogenesis of interferon-induced necrosis of subcutaneous tumors in mice. J Natl Cancer Inst 1989 in press
Elia G, Ferrantini M, Belardelli F, Proietti E, Gresser I, Amici C, Benedetto A (1988) Wheat germ agglutinin-binding protein changes in highly malignant Friend leukemia cells metastasizing to the liver. Clin Exp Metastasis 6:347–362
Glasgow LA, Kern ER (1981) Effect of interferon administration on pulmonary osteogenic sarcomas in an experimental murine model. J Natl Cancer Inst 67:207–210
Gresser I (1977) Antitumor effects of interferon. In: Becker F (ed) Cancer — a comprehensive treatise. Chemotherapy. Plenum, New York, pp 521–571
Gresser I (1985) How does interferon inhibit tumor growth? In: Gresser I (ed) Interferon 6. Academic, New York, pp 93–126
Gresser I, Bourali-Maury C (1972) Inhibition by interferon preparations of a solid malignant tumour and pulmonary metastases in mice. Nature New Biol 64:78–79
Gresser I, Belardelli F, Maury C, Tovey MG, Maunoury MT (1986b) Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. IV. Définition of optimal treatment regimens. Int J Cancer 38:251–257
Gresser I, Belardelli F, Tavernier J, Fiers W, Podo F, Federico M, Carpinelli G, Duvillard P, Prade M, Maury C, Bandu MT, Maunoury MT (1986a) Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. V. Comparisons with the action of tumor necrosis factor. Int J Cancer 38:771–778
Gresser I, Maury C, Belardelli F (1987) Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. VI. Adjuvant therapy after surgery in the inhibition of liver and spleen metastases. Int J Cancer 39:789–792
Gresser I, Maury C, Woodrow D, Moss J, Grütter MG, Vignaux F, Belardelli F, Maunoury MT (1988a) Interferon treatment markedly inhibits the development of tumor metastases in the liver and spleen and increases survival time of mice after intravenous inoculation of Friend erythroleukemia cells. Int J Cancer 41:135–142
Gresser I, Maury C, Belardelli F, Maunoury MT, Machover D (1988b) Mouse interferon a/ß is more effective than single agent chemotherapy in increasing the survival time of mice after intravenous inoculation of Friend erythroleukemia cells. J Natl Cancer Inst 80:126–131
Locardi C, Belardelli F, Federico M, Romeo G, Affabris E, Gresser I (1987) Effect of mouse interferon a/ß on the expression of H-2 (class I) antigens and on the levels of 2′-5′ oligoadenylate synthetase activity in interferon-sensitive and interferon-resistant Friend leukemia cell tumors in mice. J Biol Reg Homeost Agents 1:189–194
Nishimura J, Mitsui K, Ishikawa T, Tanaka U, Yamamoto R, Suhara U, Ishitusuka H (1985) Antitumor and metastatic activities of human recombinant interferon alpha A/D. Clin Exp Metastasis 3:295–304
Ramani P, Hart IR, Balkwill FR (1986) The effect of interferon on experimental metastases in immunocompetent and immunodeficient mice. Int J Cancer 37:563–568
Sakurai M, Iigo M, Ozaki A, Jett JR, Sasaki Y, Hoshi A, Saijo N (1986) Inhibitory effect of murine recombinant interferon (β) on the pulmonary metastasis of B-16 melanoma. Jpn J Cancer Res 77:774–781
Schirrmacher V (1985) Cancer metastasis: experimental approaches, theoretical concepts, and impacts for treatment strategies. Adv Cancer Res 43:173
Schirrmacher V, Shantz G, Clauer K, Komitowski D, Zimmermann HP, Lohmann-Matthes ML (1979) Tumor metastases and cell-mediated immunity in a model system in DBA/2 mice. I. Tumor invasiveness in vitro and metastasis formation in vivo. Int J Cancer 23:233–244
Schirrmacher V, Altevogt P, Fogel M, Dennis J, Waller CA, Barz D, Schwartz R, Cheing-song-Popov R, Springer G, Robinson PJ, Nebe T, Brossmer W, Vlodavsky I, Paweletz N, Zimmermann HP, Uhlenbruck G (1982) Importance of cell surface carbohydrates in cancer cell adhesion, invasion and metastasis. Does sialic acid direct metastatic behavior? Invasion Metastasis 2:313–360
Ueda M, Mishima Y, Mojamdar M, Ichihashi M, Kita M, Kishida T (1986) Time-dependent suppression of melanoma metastases and natural killer cell activation by interferon. Arch Dermatol Res 278:329–334
Yokoyama T, Yoshie O, Aso H, Ebina T, Ishida N (1986) Inhibition of intravascular mouse melanoma dissemination by recombinant human interferon αA/D. Jpn J Cancer Res 77:80–84
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© 1989 Springer-Verlag Berlin Heidelberg
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Gresser, I. (1989). The Effect of Interferon on Experimental Tumor Metastases. In: Schirrmacher, V., Schwartz-Albiez, R. (eds) Cancer Metastasis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74236-1_21
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DOI: https://doi.org/10.1007/978-3-642-74236-1_21
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-50471-9
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