Abstract
A potent long-acting analogue of somatostatin, SMS 201–995 (Sandostatin®), has been reported to be effective in the treatment of acromegaly [2, 3]. The usual dose regimens used in these treatments were 2 to 3 subcutaneous injections per day. It has been observed, however, that such patterns of administration do not consistently lower plasma GH levels, due to a limited duration of action of this peptide. In order to achieve more consistent suppression of plasma GH and better therapeutic efficacy, we tried to give Sandostatin in a pulsatile way by using an infusion pump.
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References
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© 1988 Springer-Verlag, Berlin Heidelberg
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Imura, H., Kato, Y., Hattori, N. (1988). Pulsatile Administration of SMS 201–995 (Sandostatin®) in the Treatment of Acromegaly. In: Lamberts, S.W.J. (eds) Sandostatin® in the Treatment of Acromegaly. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73694-0_18
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DOI: https://doi.org/10.1007/978-3-642-73694-0_18
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