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Active Principles of Plant Origin: A Means for Studying Membrane Receptors

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Rökan
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Summary

Ever since ancient times, considerable interest has been shown in plants for therapeutic use. Nowadays, however, studies of plant extracts are no longer based on empiricism; they provide great support to fundamental research, especially for a better understanding of the mediator/receptor couples.

This applies to the study of cholinergic (atropine, muscarine, etc.), adrenergic (yohimbine, rauwolscine, etc.), dopaminergic (apomorphine, bromocriptine, etc.), purinergic (caffeine, theophylline, etc.), opiate (morphine), GABA (strychnine, muscimol, bicuculline, etc.), cardiac glycosides (gitaloxin, digitoxin), and PAF-acether receptors (ginkgolides from Ginkgo biloba).

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References

  1. . Alberici G.F., Bidart J.M., Moingeon P., Pailler S., Mondesir J.M., Goodman P.A., Bohuon C.: Ellipticine derivatives intarct with muscarinic receptors. Biochem. Pharmacol., 1985, 34, 1701–1704.

    Article  PubMed  CAS  Google Scholar 

  2. . Atlas B., Bustein Y.: Isolation of an endogenous clonidine-displacing substance from rat brain. Eur. J. Biochem., 1984, 144, 287–293.

    Article  PubMed  CAS  Google Scholar 

  3. . Baker R.W., Clothia C.H., Pauling P., Petcher T.F.: Structure and activity of muscarinic stimulants. Nature, 1971, 230, 439–445.

    Article  PubMed  CAS  Google Scholar 

  4. . Beaumont K., Chilton W.S., Yamamura H.I., Enna S.J.: Muscimol binding in rat brain: association with synaptic GABA receptors. Brain. Res., 1978, 148, 153–162.

    Article  PubMed  CAS  Google Scholar 

  5. . Birdsall N.J.M., Hulme E.C.: Muscarinic receptor subclasses. TIPS, 1983, 4, 459–463.

    CAS  Google Scholar 

  6. . Bloom F., Battenberg E., Rossier J., Ling N., Guillemin R.: Neurons containing 13-endorphin in rat brain exist separately from those containing enkephalin: immunocytochemical studies. Proc. Nat. Acad. Sci„ USA, 1978, 75, 1591.

    Article  PubMed  CAS  Google Scholar 

  7. Bowery N.G., Collins J.F., Cryer G., Inch T.D., McLaughlin N.J. : In: GabaBiochemistry and CNS functions, Mandel P., De Feudis F.V. Eds., Plenum Press, 1979, 339.

    Google Scholar 

  8. . Braquet P., Spinnewyn B., Braquet M., Bourgain R.H., Taylor J.E., Etienne A., Drieu K.: BN 52021 and related compounds: a new series of highly specific PAF-acether receptor antagonists isolated from Ginkgo biloba. Blood and Vessels, 1985, 16, 558–572.

    Article  CAS  Google Scholar 

  9. . Brookes N., Werman R.: The cooperativity of y aminobutyric action on the membrane of locust muscle fibers. Mol. Pharmac., 1973, 9, 571–579.

    CAS  Google Scholar 

  10. Burgermeister W., Klein W.L., Nirenberg M., Witkopf B.: Comparative binding studies with cholinergic ligands and histrionicotoxin at muscarinic receptors of neural cell lines. Molec. Pharmacol., 1978, 14,751–767.

    Google Scholar 

  11. Cloix J.F., Miller E., Pernollet M.G., Devynck M.A., Meyer P.: Purification d’un inhibiteur endogne de la sodium-potassium-ATPase. C.R. Acad. Sci., 1983, 296, Srie III, 231–216.

    Google Scholar 

  12. . Costa E., Rodbard D., Pert C.: Is the benzodiazepine receptor coupled to a chloride anion channel? Nature, 1979, 277, 315.

    Article  PubMed  CAS  Google Scholar 

  13. . Cox B.M., Opheim K.E., Teschemacher H., Goldstein A.: A peptide-like substance from pituitary that acts like morphine. I. Isolation. Life Sci, 1975, 16, 1771–1775.

    Google Scholar 

  14. . Curtis D.R., Hosli L., Johnston G.A.R., Johnston I.H.: Glycine and spinal inhibition. Brain Res, 1967, 5, 112.

    CAS  Google Scholar 

  15. . Daly J.W.: Adenosine receptors: targets for future drugs. J. Med. Chem., 1982, 25, 197–207.

    Article  PubMed  CAS  Google Scholar 

  16. Delva P., Wauquier I., Devynck M.A.: Chronic salt-loading and circulating inhibitor of renal NA’, K+ Atpase in rats. C.R. Acad. Sci., 1984, 299, Srie III, 867–870.

    Google Scholar 

  17. . Ehlert F.J., Roeske W.R., Yamamura H.K.: Muscarinic cholinergic receptor heterogeneity. TINS, 1982, 15, 336–338.

    Google Scholar 

  18. . Erdman E., Werdan K., Brown L.: Multiplicity of cardiac glycoside receptors in the heart. TIPS, 1985, 6, 293–295.

    Google Scholar 

  19. . Fullerton D.S., Griffin J.F., Rohrer D.C., From A.H.L., Ahmed K.: Computers: using computer graphics to study cardiac glycoside-receptor interactions. TIPS, 1985, 6, 279–282.

    CAS  Google Scholar 

  20. . Godfrain R.: Withering 200 years is not enough. TIPS, 1985, 6, 360–363.

    Google Scholar 

  21. . Godfroid J.J., Heymans F., Michel E., Redeuilh C., Steiner E., Benveniste J.: Platelet activating factor (Paf-acether): Total synthesis of 1–0-Octadecyl 2–0-acetyl SN-Glycero-3-Phosphoryl Choline. FEBS Letters.1980, 116, 161–164.

    Article  PubMed  CAS  Google Scholar 

  22. Goldberg L.I., Komli J.D.: In: Apomorphine and other dopaminomimetics, Vol I.: Basic Pharmacology, Gessa G.L., Corsini G.V. Eds., Raven Press, New-York, 1981, 273.

    Google Scholar 

  23. . Grassy C., Bonnafous M., Loiseau P., Adam Y.: Vizualization of molecular electronic effect. TIPS, 1985, 6, 57–59.

    CAS  Google Scholar 

  24. . Guidotti A., Toffano G., Costa E.: An endogenous protein modulates the affinity of GABA and benzodiazepine receptors in rat brain. Nature, 1978, 275, 553–555.

    Article  PubMed  CAS  Google Scholar 

  25. Henning G., Cloix J.J.: Chromatographie d’affinit pour la dtection d’un inhibiteur endogne humain de la Na+K+ ATPase. C.R., Acad. Sci., 1983, 297, Srie III, 295–298.

    Google Scholar 

  26. . Hill D.R., Bowery N.G.: 3H-baclofen and 3H-GABA blind to biuculline insensitive GABAHB sites in rat brain. Nature, 1981, 290, 149–152.

    Article  PubMed  CAS  Google Scholar 

  27. Hughes J., Smith T.W., Kosterlitz H.W., Fothergill L.A., Morgan B.A., Morris H.R.: Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature, 1975, 258, 577.

    Google Scholar 

  28. Johnston G.A.R.: In: GABA in nervous system function, Roberts E., Chase T.N., Tower D.B. Eds., Raven Press, New-York, 1976, 395.

    Google Scholar 

  29. . Katz A.M., Franck M.D., Messineo C., Herbette L.: Ion channels in membranes. Circulation, 1982, 65, 12.

    Article  Google Scholar 

  30. . La Bella F.S.: Is there an endogenous digitalis ? TIPS, 1982, 3, 354–355.

    Google Scholar 

  31. . Lachachi H., Plantavid H., Simon M.F., Chap H., Braquet P., Douste-Blazy L.: Inhibition of transmembrane movement and metabolism of platelet activating factor (PAF-acether) by a specific antagonist, B N 52021. Biochem. Biophy. Res. Commun., 1985, 132, 460–466.

    Article  CAS  Google Scholar 

  32. . Mohler H., Okada T.: Properties of gamma-aminobutyric acid receptor binding with (+)-’3H bicuculline methiodide in rat cerebellum. Mol. Pharmacol., 1978, 14, 256–265.

    PubMed  CAS  Google Scholar 

  33. . Noël F., Godfraind T.: Heterogeneity of Ouabain specific binding sites and Na+K+atpase inhibition in microsomes from rat heart. Biochem. Pharmacol., 1984, 33, 47–53.

    Article  PubMed  Google Scholar 

  34. . Pauling P., Datta N.: Anticholinergic substances a single consistent conformation, Proc. Nat. Acad. Sci. U.S.A., 1980, 77, 708–712.

    Article  CAS  Google Scholar 

  35. . Pert C.B., Snyder S.H.: Opiate receptor: Demonstration in nervous tissu. Science, 1973, 1 79, 1011–1014.

    Article  Google Scholar 

  36. . Philipson J.D.: Natural products as a basis for new drugs. TIPS, 1979, I, 36–38.

    Google Scholar 

  37. . Repke K.R.H., Dittrich F.: Thermodynamics of information transfer from cardiotonic steroids to receptor transport ATPase. TIPS, 1980, I, 398–402.

    Google Scholar 

  38. . Repke K.R.H., Schönfeld W.: Na+K+ATPase as the digitalis receptor. TIPS, 1984, 5, 393–397.

    CAS  Google Scholar 

  39. . Repke K.R.H.: New developments in cardiac glycoside structure-activity relationship. TIPS, 1985, 6, 275–279.

    CAS  Google Scholar 

  40. . Simon E.J., Hiller J.M., Edelman I.: Stereospecific binding of the potent narcotic analgesic (3H), Etorphine to rat-brain homogenate. Proc. Nat. Acad. Sci. USA, 1973, 70, 1947–1949.

    Article  PubMed  CAS  Google Scholar 

  41. . Stoof J.C., Kebabian J.W.: Two dopamine receptors: biochemistry, physiology and pharmacology. Life sci., 1984, 35, 2281–2296.

    CAS  Google Scholar 

  42. . Su C.: Purinergic neurotransmission and neuromodulation. Ann. Rev.Pharmacol. Toxicol., 1983, 23, 397–411.

    Article  CAS  Google Scholar 

  43. . Terenius L.: Stereospecific interaction between narcotic analgesics and a synaptic plasm a membrane fraction of rat cerebral cortex. Acta Pharmacol. Toxicol., 1973, 32, 317–320.

    CAS  Google Scholar 

  44. . Ticku M.K., Olsen R.W.: Interaction of barbiturates with dihydropicrotoxinin binding sites related to the GABA receptor-ionophore system. Life Sci, 1978, 22, 1643–1651.

    CAS  Google Scholar 

  45. . Timmermans P.B., Van Zwieten P.A.: Alpha 2 adrenoceptors: classification, localization, mechanisms. J. Med. Chem., 1982, 25, 1389–1401.

    Article  PubMed  CAS  Google Scholar 

  46. . Wilkins M.R.: Endogenous digitalis: a review of the evidence. TIPS, 1985, 6, 286–288.

    CAS  Google Scholar 

  47. . Wood P.L.: Multiple opiate receptors: support for unique mu, delta and kappa sites. Neuropharmacology, 1982, 21, 487–497.

    Article  PubMed  CAS  Google Scholar 

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© 1988 Springer-Verlag Berlin Heidelberg New York

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Plat, M. (1988). Active Principles of Plant Origin: A Means for Studying Membrane Receptors. In: Fünfgeld, E.W. (eds) Rökan. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73686-5_2

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  • DOI: https://doi.org/10.1007/978-3-642-73686-5_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-19261-9

  • Online ISBN: 978-3-642-73686-5

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