Skip to main content
SpringerLink
Log in

Antiarrhythmic Drugs

  • Book
  • © 1989

Overview

Editors:
  1. E. M. Vaughan Williams

    1. Hertford College, Oxford University, Oxford, Great Britain

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 89)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (31 chapters)

  1. Front Matter

    Pages I-XXVIII
    Download chapter PDF

  2. Introduction

    1. Front Matter

      Pages N1-N1
      Download chapter PDF

    2. Cardiac Electrophysiology

      • E. M. Vaughan Williams
      Pages 1-43

    3. Classification of Antiarrhythmic Actions

      • E. M. Vaughan Williams
      Pages 45-67

    4. Acute and Chronic Animal Models of Cardiac Arrhythmias

      • E. N. Moore, J. F. Spear
      Pages 69-85

    5. Classification of Human Arrhythmias

      • P. Coumel
      Pages 87-103

    6. Successes and Limitations of Antiarrhythmic Drug Therapy

      • D. G. Julian, J. C. Cowan
      Pages 105-120

    7. Distinguishing Potentially Lethal from Benign Arrhythmias

      • R. W. F. Campbell
      Pages 121-134

  3. Antiarrhythmic Therapy

    1. Front Matter

      Pages N2-N2
      Download chapter PDF

    2. Class I Agents

      1. Subclassification of Class I Antiarrhythmic Drugs
        • T. J. Campbell
        Pages 135-155
      2. Interaction of Class I Drugs with the Cardiac Sodium Channel
        • L. M. Hondeghem
        Pages 157-174
      3. Clinical Use of Class Ia Antiarrhythmic Drugs
        • T. J. Campbell
        Pages 175-199
      4. Clinical Use of Class Ib Antiarrhythmic Drugs
        • D. W. G. Harron, R. G. Shanks
        Pages 201-233
      5. Clinical Use of Class Ic Antiarrhythmic Drugs
        • J. C. Somberg
        Pages 235-277

    3. Class II Agents

      1. Arrhythmias in the Normal Human Heart
        • P. Taggart
        Pages 279-301
      2. Adrenergic Arrhythmogenicity
        • E. M. Vaughan Williams
        Pages 303-308
      3. Antiarrhythmic Properties of Beta-Adrenoceptor Blockade During and After Myocardial Infarction
        • P. Sleight, P. Rossi
        Pages 309-322

    4. Class III Agents

      1. Class III Antiarrhythmic Action
        • S. B. Olsson
        Pages 323-334
      2. Amiodarone: Electropharmacologic Properties
        • B. N. Singh
        Pages 335-364
      3. Sotalol
        • S. M. Cobbe
        Pages 365-387
Back to top

Keywords

About this book

The development of a new antiarrhythmic drug involves many people with disparate skills. The organic chemist who makes it is guided not only by the structure-action relations of previous compounds, but by anticipation of a requirement for a particular type of action. In fact several of the best-known antiarrhythmics, including lidocaine, mexiletine, amiodarone and verapamil, were originally synthesized for other purposes. Physicians have to determine whether the new drug works, and pharma­ cologists how it works. For some years I have believed that there was room for a work which could be understood by all these groups and which could enlighten each about the point of view of the others. Thus when I was invited by Springer-Verlag to prepare a volume in their series Handbook of Experimental Pharmacology, I already had a firm conception of what its form should be. In any multi-author work there are two objectives which cannot always readily be reconciled. The first is to select topics which would relate to each other in a coherent manner. to give a logical and orderly shape to the volume as a whole. The second is to offer authors the greatest possible freedom to express themselves as they wish. When the general design was complete, prospective contributors were invited to write specific chapters, being provided with a complete list of their coauthors and chosen topics, so that they could avoid overlap.

Editors and Affiliations

  • Hertford College, Oxford University, Oxford, Great Britain

    E. M. Vaughan Williams

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation