Skip to main content

Postmortem Neurochemical Investigation of Suicide

  • Conference paper
Current Issues of Suicidology

Abstract

Several neurochemical mechanisms can be implicated in suicidal behavior — not as causal factors but rather as biological components of this very complex phenomenon. Most investigators have measured levels of various monoamine metabolites and hormones in body fluids of suicide attempters only. However, completed suicide and attempted suicide have been shown to be statistically distinct on demographic and diagnostic grounds. Another shortcoming of these studies is the various time intervals between the suicidal act and the timing of sampling. In this way, only permanent neurochemical abnormalities could be detected — trait markers. With postmortem sampling shortly after death, we can obtain more accurate information about the actual condition of the central nervous and endocrine systems at the time of death. Encouraged by a recent study (Stanley et al. 1985) and our own preliminary findings (Arató et al. 1985 a), we have tried to use postmortem measurements as a new research tool to explore the neurochemical background of suicides.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Arató M, Falus A, Tóthfalusi L, Magyar K, Sótonyi P, Somogyi E (1985 a) Postmortem cerebrospinal fluid measurements in suicide. 13th Congress Int Acad Legal Med Soc Med, September 1985, Budapest

    Google Scholar 

  • Arató M, Bánki CM (1985 b) Hypothalamic-pituitary-adrenal axis and suicide. Conf Psychobiol Suic Behav. The New York Academy of Science, September, New York

    Google Scholar 

  • Åsberg M, Edman G, Rydin E, Schalling D, Träskman-Bendz L, Wagner A (1984) Biological correlates of suicidal behaviour. Clin Neuropharmacol 7 (suppl 1): 758–759

    Google Scholar 

  • Bánki CM, Arató M, Papp Z, Kurcz M (1984) Biochemical markers in suicidal patients. Investigations with cerebrospinal fluid amine metabolites and neuroendocrine tests. J Affective Disord 6:341–350

    Article  Google Scholar 

  • Brown GL, Ebert MH, Goyer PF, Jimerson DC, Klein WJ, Bunney WE, Goodwin FK (1982) Aggression, suicide and serotonin: relationship to CSF amine metabolites. Am J Psychiatry 139:741–746

    PubMed  CAS  Google Scholar 

  • Bunney WE, Fawcett JA (1965) Possibility of a biochemical test for suicidal potential: an analysis of endocrine findings prior to three suicides. Arch Gen Psychiatry 13:232–239

    Article  PubMed  CAS  Google Scholar 

  • Cahill CA, Matthews JD, Akil H (1983) Human plasma β-END like peptides: a rapid, high recovery extraction technique and validation of radioimmunoassay. J Clin Endocrinol Metab 56:992–997

    Article  PubMed  CAS  Google Scholar 

  • Kauert G, Gilg T, Eisenmenger W, Spann W (1984) Postmortem biogenic amines in CSF of suicides and controls. College Int Neuro-Psychopharmacol 1984, Florence

    Google Scholar 

  • Krieger G (1974) The plasma level or Cortisol as a predictor of suicide. Dis Nerv Syst 35:237–240

    PubMed  CAS  Google Scholar 

  • Linnoila M, Virkkunen M, Scheinin M, Muutila A, Rimon R, Goodwin FK (1983) Low cerebrospinal fluid 5-hydroxyindolacetic acid concentration differentiates impulsive from nonimpulsive violent behaviour. Life Sci 33:2609–2614

    Article  PubMed  CAS  Google Scholar 

  • Murphy BEP (1967) Some studies of the protein-binding of steroids and their application to the routine micro and ultra-micro measurement of various steroids in body fluids by competitive protein-binding radioassay. J Clin Endocrinol Metab 27:973–990

    Article  PubMed  CAS  Google Scholar 

  • Palfreyman MG, Huout S, Wagner J (1982) Value of monoamine metabolite determinations in CSF as an index of their concentrations in rat brain. J Pharmacol Methods 8:183–196

    Article  PubMed  CAS  Google Scholar 

  • Roy A, Pickar D, Linnoila M, Doran AR, Paul SM (1986) Cerebrospinal fluid monoamine and monoamine metabolite levels and the dexamethasone suppression test in depression. Arch Gen Psychiatry 43:356–360

    Article  PubMed  CAS  Google Scholar 

  • Siever LJ, Davis KL (1985) Overview: toward a dysregulation hypothesis of depression. Am J Psychiatry 142:1017–1031

    PubMed  CAS  Google Scholar 

  • Stanley M, Träskman-Bendz L, Dorovin-Zis K (1985) Correlation between aminergic metabolites simultaneously obtained from human CSF and brain. Life Sci 37:1279–1286

    Article  PubMed  CAS  Google Scholar 

  • Träskman L, Tybing G, Åsberg M, Bertilsson L, Lantto O, Schalling D (1980) Cortisol in the CSF of depressed and suicidal patients. Arch Gen Psychiatry 37:761–767

    Article  PubMed  Google Scholar 

  • Träskman-Bendz L, Åsberg M, Bertilsson L, Thoren P (1984) CSF monoamine metabolites of depressed patients during illness and after recovery. Acta Psychiatr Scand 69:332–342

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Arató, M. et al. (1988). Postmortem Neurochemical Investigation of Suicide. In: Möller, HJ., Schmidtke, A., Welz, R. (eds) Current Issues of Suicidology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73358-1_33

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73358-1_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73360-4

  • Online ISBN: 978-3-642-73358-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics