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Regenerative, AlI-or-None, Electrographic Seizures in the Rat Hippocampal Slice in Physiological Magnesium Medium

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Synaptic Plasticity in the Hippocampus

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Abstract

Previous studies have shown that electrographic seizures (EGSs) can occur spontaneously for several hours in the hippocampal slice in Mg-free medium containing the GABAb agonist baclofen. We report here that similar all-or-none EGSs could be triggered in physiological Mg medium (with or without baclofen) if the EGSs were induced by several stimulus trains, and sometimes transiently exposed to Mg-free medium.

Supported by the Veterans Administration and NIH Grant NS-17771.

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References

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Author information

Authors and Affiliations

  1. Departments of Pharmacology, Medicine and Psychology, Duke University, 27706, Durham, NC, USA

    W. W. Anderson, H. S. Swartzwelder & W. A. Wilson

  2. Epilepsy Center, V.A. Medical Center, 27706, Durham, NC, USA

    W. W. Anderson, H. S. Swartzwelder & W. A. Wilson

Authors
  1. W. W. Anderson
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  2. H. S. Swartzwelder
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  3. W. A. Wilson
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Editor information

Editors and Affiliations

  1. II. Physiologisches Institut, Johannes Gutenberg-Universität, Saarstrasse 21, 6500, Mainz, Germany

    Helmut L. Haas M.D.

  2. Department of Neurosciences MO24, University of California at San Diego, 92093, La Jolla, CA, USA

    György Buzsàki M.D.

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© 1988 Springer-Verlag Berlin Heidelberg

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Anderson, W.W., Swartzwelder, H.S., Wilson, W.A. (1988). Regenerative, AlI-or-None, Electrographic Seizures in the Rat Hippocampal Slice in Physiological Magnesium Medium. In: Haas, H.L., Buzsàki, G. (eds) Synaptic Plasticity in the Hippocampus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73202-7_51

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  • DOI: https://doi.org/10.1007/978-3-642-73202-7_51

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73204-1

  • Online ISBN: 978-3-642-73202-7

  • eBook Packages: Springer Book Archive

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