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An APV-Resistant Non-associative Form of Long-Term Potentiation in the Rat Hippocampus

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Synaptic Plasticity in the Hippocampus

Abstract

Single pyramidal cells of the CA3 region of the hippocampus receive synaptic inputs from two distinct pathways (commissural and mossy fiber) which both exhibit long term potentiation (LTP), but only the commissural LTP is blocked by an NMDA antagonist. Brief tetanization to neighboring synapses fails to potentiate mossy fiber inputs but does potentiate commissural inputs. Thus CA3 pyramidal cells receive synaptic inputs which express fundamentally different forms of synaptic plasticity.

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Author information

Authors and Affiliations

  1. Departments of Pharmacology and Physiology, University of California, 94143, San Francisco, CA, USA

    J. A. Kauer & R. A. Nicoll

Authors
  1. J. A. Kauer
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  2. R. A. Nicoll
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Editor information

Editors and Affiliations

  1. II. Physiologisches Institut, Johannes Gutenberg-Universität, Saarstrasse 21, 6500, Mainz, Germany

    Helmut L. Haas M.D.

  2. Department of Neurosciences MO24, University of California at San Diego, 92093, La Jolla, CA, USA

    György Buzsàki M.D.

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© 1988 Springer-Verlag Berlin Heidelberg

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Kauer, J.A., Nicoll, R.A. (1988). An APV-Resistant Non-associative Form of Long-Term Potentiation in the Rat Hippocampus. In: Haas, H.L., Buzsàki, G. (eds) Synaptic Plasticity in the Hippocampus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73202-7_19

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  • DOI: https://doi.org/10.1007/978-3-642-73202-7_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73204-1

  • Online ISBN: 978-3-642-73202-7

  • eBook Packages: Springer Book Archive

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