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Viral Interactions with Pancreatic B-Cells

  • Chapter
The Pathology of the Endocrine Pancreas in Diabetes

Abstract

It has long been hypothesized that viruses play an important role in the etiology of some forms of insulin-dependent diabetes mellitus (IDDM). This hypothesis began to develop following the initial report of an association between community outbreaks of mumps and the occurrence of IDDM [38] and was supported by the discovery of a seasonal variation in the incidence of new cases of IDDM [27]. Subsequent studies have suggested correlations between rubella [21, 50, 73] cytomegalovirus [43], reovirus [109] and group B Coxsackie virus [28] infections and IDDM. Additionally, the description of B-cell death associated with insulitis, as eloquently described by Gepts [31] has been considered to be consistent with the pathogenesis of an ongoing viral infection.

This work was supported by research grants AM 17631, AM 27722, and AM 36175 from the National Institute of Arthritis, Diabetes, Digestive, and Kidney Diseases to EHL and by research grants ES 03456 and a Research Career Development Award ES 00150 from the National Institute of Environmental Health Sciences to GLW.

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  1. E. H. Leiter
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  2. G. L. Wilson
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Editors and Affiliations

  1. Division of Diabetes, Nutrition and Metabolic Disorders Department of Medicine, Centre Hospitalier Universitaire du Sart-Tilman, B-4000, Liège 1, Belgium

    Pierre J. Lefèbvre

  2. Dept. of Metabolism and Endocrinology, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090, Brussels, Belgium

    Daniel G. Pipeleers

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Leiter, E.H., Wilson, G.L. (1988). Viral Interactions with Pancreatic B-Cells. In: Lefèbvre, P.J., Pipeleers, D.G. (eds) The Pathology of the Endocrine Pancreas in Diabetes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72691-0_6

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