Abstract
It is a misconception particularly prevalent amongst European paediatric oncologists that, because sarcoma has a propensity to metastasise, therefore only systemic therapy has a major role in management or is logical [1,2].
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References
Flamant F, Rodary C, Voute PA, Otten J (1985) Primary chemotherapy in the treatment of rhabdomyosarcoma in children: Trial of the International Society of Pediatric Oncology (SIOP) preliminary results. Radiother Oncol 3:227–236
Otten J, Flamant F, Rodary C, et al (1985) Effectiveness of combination of ifosfamide, vincristine and actinomycin D in inducing remission in rhabdomyosarcoma in children. Proc Am Soc Clin Oncol 4:236 [Abstract C-917]
Skipper HE (1971) Kinetic behavior versus response to chemotherapy. Monogr Natl Cancer Inst 34:2–14
Skipper HE, Schabel FM, Mellett JB, Montgomery JA, Wilkoff LJ, Lloyd HH, Rockman RW (1970) Implications of biochemical, cytokinetic, pharmacologic and toxicologic relationships in the design of optimal therapeutic schedules. Cancer Chemother Rep 54:431–450
Skipper HE (1978) Cancer chemotherapy 1: Reasons for success and failure of treatment of murine leukaemias with drugs now employed in treating human leukaemias. Ann Arbor University Microfilms International 1978
Baker RM, Ling V (1978) Numbering mutants of mammalian cells in culture. In: Korn ED (ed) Methods in membrane biology. Plenum, New York, pp 337–384
Heppner GH, Dexter DL, De Nucci T, Miller FR, Calabres P (1978) Heterogeneity in tumour sensitivity among tumour cell subpopulations of a single mammary tumour. Cancer Res 38:3758–3763
Law LW (1952) Origins of the resistance of leukaemic cells to folic acid antagonists. Nature 169:628–629
Ling V (1978) Genetic aspects of drug resistance in somatic cells. In: Schabel FM (ed) Antibiotics and chemotherapy. Karger, Basel, pp 191–200
Goldie JH, Coldman AJ (1979) A mathematical model for relating the drug sensitivity of tumours to their spontaneous mutation rate. Cancer Treat Rep 63:172–182
Goldie JH, Coldman AJ, Gudauskas GA (1982) Rationale for the use of alternating non-cross-resistant chemotherapy. Cancer Treat Rep 66:439–449
Ling V (1975) Drug resistance and membrane alteration in mutants of mammalian cells. Can J Genet Cytol 17:503–515
Steel GG: Growth kinetics of tumours
Griffiths CT, Parker LM, Fuller AF (1979) Role of cytoreductive surgical treatment in the management of advanced ovarian cancer. Cancer Treat Rep 63:235–240
Suit HD (1975) Role of therapeutic radiology in cancer of bone. Cancer 35:930–935
Green DM, Jaffe N (1978) Progress and controversy in the treatment of childhood rhabdomyosarcoma. Cancer Treat Rev 5:7–27
Cassady JR, Sagerman RH, Tretter P, Ellesworth RM (1963) Radiation therapy for rhabdomyosarcoma. Radiology 91:116–120
Kingston JE, McElwain TJ, Malpas JS (1983) Childhood rhabdomyosarcoma: Experience of the children’s solid tumour group. Br J Cancer 48:195–207
Sutow WW, Lindberg RD, Gehan EA, et al (1982) Three year relapse-free survival rates in childhood rhabdomyosarcoma of the head and neck. Cancer 49:2217–2221
Hays DM, Raney RB, Lawrence W, Soule EH, Gehan EA, Tefft M (1982) Bladder and prostatic tumours in the intergroup rhabdomyosarcoma study (IRS-1). Cancer 50:1472–1482
Hays DM, Raney RB, Lawrence W, et al (1982) Primary chemotherapy in the treatment of children with bladder-prostate tumours in the intergroup rhabdomyosarcoma study (IRS-2). J Pediatr Surg 17:812–820
Jereb B, Ghavimi F, Exelby P, Zang E (1980) Local control of embryonal rhabdomyosarcoma in children by radiotherapy when combined with chemotherapy. Int J Pediat Oncol Biol Phys 6:825–833
Donaldson S (1985) The value of adjuvant chemotherapy in the management of sarcomas in children. Cancer 55:2185–2197
Ewing J (1921) Diffuse endothelioma of bone. Proc NY Pathol Soc 21:17–24
Fernandez CH, Lindberg RD, Sutow WW, Samuels ML (1974) Localised Ewing’s sarcoma treatment and results. Cancer 34:143–148
Chabora BM, Rosen G, Chan W, D’Angio GJ, Tefft M (1976) Radiotherapy of Ewing’s sarcoma. Radiology 120:667–671
Rosen G, Caparros B, Nirenberg A, et al (1981) Ewing’s sarcoma: ten year experience with adjuvant chemotherapy. Cancer 47:2204–2213
Thomas PRM, Foulkes MA, Gilula LA, et al (1983) Primary Ewing’s sarcoma of the ribs. A report from the Intergroup Ewing’s Sarcoma Study. Cancer 51:1021–1027
Li WK, Lane JM, Rosen G, et al (1983) Pelvic Ewing’s sarcoma. J Bone Joint Surg 65-A:738–747
Thomas PRM, Perez CA, Neff JR, Nesbit ME, Evans RG (1984) The management of Ewing’s sarcoma: Role of radiotherapy in local tumour control. Cancer Treat Rep 68:703–710
Jürgens H, Gobel V, Etspuler G, et al (1985) Factors influencing the prognosis of children and adolescents with primary Ewing’s sarcoma of bone. Proc Am Soc Clin Oncol 4:239 [Abstract C-929]
Perez CA, Tefft M, Nesbit M, et al (1981) The role of radiation therapy in the management of non-metastatic Ewing’s sarcoma of bone. Report of the Intergroup Ewing’s sarcoma study. Int J Radiat Oncol Biol Phys 7:141–149
Tefft M, Razek A, Perez C, et al (1978) Local control and survival related to radiation dose and volume and to chemotherapy in non-metastatic Ewing’s sarcoma of pelvic bones. Int J Radiat Oncol Biol Phys 4:367–372
Perez CA, Razek A, Tefft M, et al (1977) Analysis of local tumour control in Ewing’s sarcoma. Cancer 40:2864–2873
Pomeroy TC, Johnson RE (1975) Prognostic factors for survival in Ewing’s sarcoma. Am J Roentgenol 123:598–606
Rosen G (1987) Primary Ewing’s sarcoma. The multidisciplinary lesion. Int J Radiat Oncol Biol Phys 4:527–532
Rosen G, Caparros B, Mosende C, McCormick B, Huvos AG, Marcove RC (1978) Curability of Ewing’s sarcoma and considerations for future therapeutic trials. Cancer 41:888–899
Plowman PN, Shand WS, Jackson DB (1984) Use of absorbable mesh to displace bowel and avoid radiation enteropathy, during therapy of pelvic Ewing’s sarcoma. Human Toxicol 3:229–237
Lewis RJ, Marcove RC, Rosen G (1977) Ewing’s sarcoma — functional effects of radiation therapy. J Bone Joint Surg 59:325–331
Jentzsch K, Binder H, Cramer H (1981) Leg function after radiotherapy for Ewing’s sarcoma. Cancer 47:1267–1278
Tefft M, Chabora B, Rosen G (1977) Radiation in bone sarcomas. A re-evaluation in the era of intensive systemic chemotherapy. Cancer 39:806–816
Suit HD (1975) Role of therapeutic radiology in cancer of bone. Cancer 35:930–935
Ong RL, Jereb B, Caparros B, Exelby P (1984) Re-defined role of radiation in combined treatment of Ewing’s sarcoma. Int J Radiat Oncol Biol Phys [Suppl 2] 10:170 [Abstract 1048]
Jaffe N, Farber S, Traggis D, et al (1973) Favourable response of osteogenic sarcoma to high dose methotrexate with citrovorum rescue and radiation therapy. Cancer 31:1367–1375
Rosen G (1976) Management of malignant bone tumours. In: Evans AE, D’Angio GJ, Koop CE (eds) Pediatric clinics of North America. Saunders, Philadelphia, p 183
Rosen G, Caparros B, et al (1982) Pre-operative chemotherapy for osteogenic sarcoma. Selection of post-operative adjuvant chemotherapy based on the response of the primary tumour to pre-operative chemotherapy. Cancer 41:1221–1230
Eilber FR, Eckardt J (1985) Adjuvant therapy for osteogenic sarcoma: a randomised prospective trial. Proc Am Soc Clin Oncol 4:144 [Abstract C-561]
Link M, Goorin A, Miser A, et al (1985) The role of adjuvant chemotherapy in the treatment of osteosarcoma of the extremity: preliminary results of the multi-institutional osteosarcoma study. Proc Am Soc Clin Oncol 4:237 [Abstract C-924]
Morton DL, Storm FK, Eilber FR (1985) Surgical management and limb salvage in osteogenic sarcoma. In: D’Angio GJ, Evans AE (eds) Bone tumours and soft tissue sarcomas. Arnold, London, pp 134–139
Plowman PN (1985) Radiotherapy. In: Zingg EJ, Wallace DMA (eds) Bladder cancer. Berlin Heidelberg New York, pp 207–221
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Plowman, P.N. (1989). Bulk Disease as the Major Problem in the Cure of Paediatric Sarcomas. In: Spitz, L., Wurnig, P., Angerpointner, T.A. (eds) Pediatric Surgical Oncology. Progress in Pediatric Surgery, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72643-9_3
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DOI: https://doi.org/10.1007/978-3-642-72643-9_3
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