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p21/p53, Cellular Growth Control and Genomic Integrity

  • Chapter
Cyclin Dependent Kinase (CDK) Inhibitors

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 227))

Abstract

In the short time since its discovery in 1993, the prototype cyclin-dependent kinase (CDK) inhibitor p21 (CIP1, Harper et al. 1993; WAF1, El-Deiry et al. 1993; p21, Xiong et al. 1993a; CAP20, Gu et al. 1993; SDI1, Noda et al. 1994; MDA6, Jiang et al. 1995) has become an intensely studied molecule. Much has been learned about its molecular structure, biochemical interactions, and physiological role. p21 is a focal point that integrates many types of signals that impact on processes of cell division and cell death. Since 1995 to date there have been over 600 references in Current Contents dealing with WAF1 or CIP1 and they are increasing at a rate of up to 25 per week. The p53 field which dates back to 1979 has had some 6000 references on Medline since 1993. This chapter will highlight some of the recent discoveries emphasizing the role of p21 and p53 in growth control and the maintenance of genomic integrity.

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Authors and Affiliations

  1. Laboratory of Molecular Oncology and Cell Cycle Regulation, Howard Hughes Medical Institute, Department of Medicine, Genetics and Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    W. S. El-Deiry

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  1. W. S. El-Deiry
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  1. Division of Oncovirology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, SBR7, Rm. SR311, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Peter K. Vogt Ph.D.

  2. Department of Molecular Medicine, MB-7, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Steven I. Reed Ph.D.

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© 1998 Springer-Verlag Berlin Heidelberg

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El-Deiry, W.S. (1998). p21/p53, Cellular Growth Control and Genomic Integrity. In: Vogt, P.K., Reed, S.I. (eds) Cyclin Dependent Kinase (CDK) Inhibitors. Current Topics in Microbiology and Immunology, vol 227. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71941-7_6

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  • DOI: https://doi.org/10.1007/978-3-642-71941-7_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71943-1

  • Online ISBN: 978-3-642-71941-7

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