Abstract
The presently available data on pharmacokinetics of halogenated solvents which produce hepatic tumors in B6C3F1 mice, but not in rats, are reviewed. Such compounds are trichloroethylene, perchloroethylene, 1,1,2- trichloroethane, 1,1,2,2-tetrachloroethane, and dichloromethane. It seems likely that higher metabolic rates in mice (compared with other species) may lead to a species-selective toxicity of such compounds. Recurrent cytotoxicity which leads to stimulation of cell replication seems to be a contributing factor in the pathogenesis of mouse liver tumors. However, it is likely that more than one factor contributes to the unique tumor response of the B6C3F1 mouse.
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Bolt, H.M. (1987). Pharmacokinetic Factors and Their Implication in the Induction of Mouse Liver Tumors by Halogenated Hydrocarbons. In: Chambers, P.L., Henschler, D., Oesch, F. (eds) Mouse Liver Tumors. Archives of Toxicology, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71617-1_18
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DOI: https://doi.org/10.1007/978-3-642-71617-1_18
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