Abstract
The covalent binding of 3H-styrene oxide to amino acids, and whole human blood was investigated in vitro. After reaction, serum, and red cells were separated, and proteins were digested into amino acids; styrene oxide derivatives were isolated by HPLC. The order of binding to free amino acids was cysteine ≫ histidine > lysine > serine. In serum proteins and hemoglobin cysteine-derivatives predominated. When styrene oxide was reacted with free cysteine and with proteins two isomers were observed. These were likely to present binding through the α and β carbon of styrene oxide, and their abundance was about 2:1.
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© 1986 Springer-Verlag
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Hemminki, K. (1986). Binding of Styrene Oxide to Amino Acids, Human Serum Proteins and Hemoglobin. In: Chambers, C.M., Chambers, P.L., Tuomisto, J. (eds) Toxic Interfaces of Neurones, Smoke and Genes. Archives of Toxicology, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71248-7_46
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DOI: https://doi.org/10.1007/978-3-642-71248-7_46
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16589-7
Online ISBN: 978-3-642-71248-7
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