Abstract
In 1976 we designed a treatment protocol for children with acute myelogenous leukemia (AML) that featured a cytokinetically based induction regimen and 30 months of maintenance chemotherapy employing vincristine-doxorubicin-cyclophosphamide, cytarabine, and 6-mercaptopurine [1]. The intent was to determine if relatively nontoxic chemotherapy would cure a significant number of patients, with the benefit of fewer adverse side effects. About one-third of the patients were randomized to a splenectomy group in an effort to determine if the spleen is a clinically important sanctuary for leukemic cells. In 1980 we drastically changed our therapeutic strategy to an intensive induction followed by either sequential intensive chemotherapy or bone marrow transplantation [2].
Supported by grants CA-20180 and CA-21765 from the National Cancer Institute, and by the American Lebanese Syrian Associated Charities (ALSAC).
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References
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© 1987 Springer-Verlag Berlin Heidelberg
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Dahl, G.V., Kalwinsky, D.K., Mirro, J., Look, A.T. (1987). A Comparison of Cytokinetically Based Versus Intensive Chemotherapy for Childhood Acute Myelogenous Leukemia. In: Büchner, T., Schellong, G., Hiddemann, W., Urbanitz, D., Ritter, J. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71213-5_14
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DOI: https://doi.org/10.1007/978-3-642-71213-5_14
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