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The Development of a Practical Total Synthesis of Natural and Unnatural Codeine, Morphine and Thebaine

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The Chemistry and Biology of Isoquinoline Alkaloids

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

In this report, a brief overview of the history of the chemistry and pharmacology of the opium alkaloids will be presented in order to place recent progress in opiate total synthesis in proper perspective. After a brief description of how past, present and possible future developments influenced the development of the NIH opiate total synthesis, some recent progress in this area will be described.

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Author information

Authors and Affiliations

  1. Section on Medicinal Chemistry, Laboratory of Chemistry, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, National Institute of Health, Bldg 4, Rm 135, Bethesda, Maryland, 20205, USA

    K. C. Rice

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  1. K. C. Rice
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Editors and Affiliations

  1. Department of Pharmacognosy, The School of Pharmacy, Brunswick Square, WC1N 1AX, London, UK

    J. David Phillipson  & Margaret F. Roberts  & 

  2. Pharmazeutische Biologie, Universität München, Karlstraße 29, 8000, München 2, Germany

    M. H. Zenk

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© 1985 Springer-Verlag Berlin Heidelberg

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Rice, K.C. (1985). The Development of a Practical Total Synthesis of Natural and Unnatural Codeine, Morphine and Thebaine. In: Phillipson, J.D., Roberts, M.F., Zenk, M.H. (eds) The Chemistry and Biology of Isoquinoline Alkaloids. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70128-3_12

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  • DOI: https://doi.org/10.1007/978-3-642-70128-3_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70130-6

  • Online ISBN: 978-3-642-70128-3

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