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The Selective Origin of Linkage Disequilibrium in the HLA Region

  • Conference paper
Histocompatibility Testing 1984

  • 13 Accesses

Abstract

The linkage disequilibrium patterns observed between tightly linked loci, such as the HLA loci, can indicate the nature of evolutionary events, particularly selection events, acting on the region. We have developed a method, disequilibrium pattern analysis, for examining the disequilibrium distribution of a population of two-locus haplotypes. Specific quantifiable patterns are predicted as a result of selective events.

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Reference

  1. Hansen HE, Larsen SO, Ryder LP, Nielsen LS (1979) HLA-A, B haplotype frequencies in 5202 unrelated Danes by a maximum likelihood method of gene counting. Tissue Antigens 13: 143–153

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Author information

Authors and Affiliations

  1. Genetics Department, University of California, Berkeley, 94720, CA, USA

    W. Klitz & G. Thomson

Authors
  1. W. Klitz
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  2. G. Thomson
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Editor information

Editors and Affiliations

  1. Labor für Immungenetik, Kinderpoliklinik der Universität, Pettenkoferstraße 8a, 8000, München 2, Bundesrepublik Deutschland

    Ekkehard D. Albert

  2. Biometrische Abteilung, Diabetes Forschungsinstitut an der Universität, Auf’m Hennekamp 65, 4000, Düsseldorf 1, Bundesrepublik Deutschland

    Max P. Baur

  3. Institut für Blutgruppenserologie der Universität, Spitalgasse 4, 1090, Wien, Österreich

    Wolfgang R. Mayr

  4. Essen, Germany

    J. Bertrams  & H. Grosse-Wilde  & 

  5. Ulm, Germany

    S. Goldmann

  6. Heidelberg, Germany

    G. Opelz

  7. Bonn, Germany

    C. Rittner

  8. Munich, Germany

    D. J. Schendel , S. Scholz  & R. Wank ,  & 

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© 1984 Springer-Verlag Berlin Heidelberg

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Klitz, W., Thomson, G. (1984). The Selective Origin of Linkage Disequilibrium in the HLA Region. In: Albert, E.D., et al. Histocompatibility Testing 1984. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69770-8_218

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  • DOI: https://doi.org/10.1007/978-3-642-69770-8_218

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69772-2

  • Online ISBN: 978-3-642-69770-8

  • eBook Packages: Springer Book Archive

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