Skip to main content

C4 Polymorphism

  • Conference paper
Histocompatibility Testing 1984

Abstract

Eighty laboratories have contributed data on class III gene products to the Ninth International Histocompatibility Workshop. Therefore, it can be concluded that these investigations of complement markers in studies on population genetics and disease associations reflect the increasing importance of the class III loci of the major histocompatibility complex. The study of the highly polymorphic C4 loci, in particular, poses a number of problems, only some of which can be addressed in this report. For a more detailed discussion the reader may consult some recent publications [6, 10, 12, 14]. The results of the association studies of C2, BF, C4A, and C4B in the workshop diseases will be found in the disease reports in this volume.

This work was supported in part by Deutsche Forschungsgemeinschaft Ri 164/16-1 and Ma 848/1

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Awdeh ZL, Alper CA (1980) Inherited structural polymorphism of the fourth component of human complement. Proc Natl Acad Sci USA 77: 3576–3580

    Article  PubMed  CAS  Google Scholar 

  2. Carroll MC, Campbell RD, Bentley DR, Porter RR (1984) A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B. Nature 307: 237–241

    Google Scholar 

  3. Carroll MC, Belt KT, Palsdottir A, Yu CY, Porter RR (1984) Structural studies on the human fourth component of complement genes and their products. Third H-2, HLA Cloning Meeting, Strasbourg, 2–4 May

    Google Scholar 

  4. Mauff G, Alper CA, Awdeh ZL, Batchelor JR, Bertrams J, Bruun-Petersen G, Dawkins RL, Démant P, Edwards JH, Grosse-Wilde H, Hauptmann G, Klouda P, Lamm L, Mollenhauer E, Nerl C, Olaisen B, O’Neill G, Rittner C, Roos MH, Skanes V, Teisberg P, Wells L (1983) Statement on the nomenclature of human C4 allotypes. Im- munobiol 164: 184–191

    CAS  Google Scholar 

  5. Mauff G, Steuer M, Week M, Bender K (1983) The Cap-chain: evidence for a genetically determined polymorphism. Hum Genet 64: 186–188

    Article  PubMed  CAS  Google Scholar 

  6. Mauff G, Bender K, Giles CM, Goldmann S, Opferkuch W, Wachauf B (1984) Human C4 polymorphism: Pedigree analysis of qualitative, quantitative, and functional parameters as a basis for phenotype interpretations. Hum Genet 65: 362–372

    Google Scholar 

  7. Olaisen B, Teisberg P, Jonassen R, Thorsby E, Gedde-Dahl T Jr (1983) Gene order and gene distance in the HLA region studied by the haplotype method. Ann Hum Genet 47: 285–292

    Article  PubMed  CAS  Google Scholar 

  8. O’Neill GJ, Yang SY, Dupont B (1978) Two HLA-linked loci controlling the fourth component of human complement Proc Natl Acad Sci USA 75: 5165–5169

    Google Scholar 

  9. Rittner C, Tippett P, Giles CM, Mollenhauer E, Berger R, Nordhagen R, Buskjoer L, Bruun-Petersen G, Lamm L, Roos MH (1984) An international reference typing for Ch and Rg determinants on rare human C4 allotypes. Vox Sang. 46: 224–234

    Article  PubMed  CAS  Google Scholar 

  10. Rittner C, Giles CM, Roos MH, Demant P, Mollenhauer E (1984) Genetics of human C4 polymorphism: detection and segregation of rare and duplicated haplotypes. Im- munogenetics 19: 321–333

    CAS  Google Scholar 

  11. Roos MH, Mollenhauer E, Demant P, Rittner C (1982) A molecular basis for the two-locus model of human complement component C4. Nature 298: 854–856

    Article  PubMed  CAS  Google Scholar 

  12. Roos MH, Demant P, Giles CM, Mollenhauer E, Rittner C (1984) Polymorphism of human C4A and C4B-chains as detected by analysis of Rodgers and Chido determinants. J Immunol (in press)

    Google Scholar 

  13. Schendel DJ, Wank R, O’Neill GJ (1984) C4 phenotypic variation suggests an unusual class III gene organization. Vox Sang (in press)

    Google Scholar 

  14. Whitehead AS, Woods DE, Fleischnick E, Chin JE, Yunis EJ, Katz AJ, Gerald PS, Alper CA, Colten HR (1984) DNA polymorphism of the C4 genes. A new marker for analysis of the major histocompatibility complex. New Engl J Med 310: 88–91

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Rittner, C., Mauff, G. (1984). C4 Polymorphism. In: Albert, E.D., et al. Histocompatibility Testing 1984. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69770-8_112

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-69770-8_112

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69772-2

  • Online ISBN: 978-3-642-69770-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics