Abstract
Cytochrome P-450-dependent monooxygenases are widely distributed in living organisms like mammals, fish, birds, yeasts and plants. In man, they exist in several organs and tissues with a maximum concentration in the liver. Some of them are in charge of the elimination of foreign compounds (xenobiotics) from the body and have to hydroxylate a broad spectrum of lipophilic compounds making them more hydrophilic and more easily excreted (Ullrich 1979). These cytochromes P-450 play a key role not only in pharmacology since they control the elimination rate of drugs, but also in toxicology since they seem to be the privileged sites of formation of reactive intermediates inside the cell.
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© 1983 Springer-Verlag Berlin Heidelberg
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Mansuy, D. (1983). Reactive Intermediates Derived from Cytochrome P-450 Monooxygenases. In: Sund, H., Ullrich, V. (eds) Biological Oxidations. Colloquium der Gesellschaft für Biologische Chemie 14.–16. April 1983 in Mosbach/Baden, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69467-7_14
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DOI: https://doi.org/10.1007/978-3-642-69467-7_14
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