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B-Cell Malignancies: Origin and Extent of Clonal Involvement

  • Conference paper
Modern Trends in Human Leukemia V

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 28))

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Abstract

Soon after it was established that normal lymphoid development proceeds along two distinct pathways of differentiation, it was recognized that lymphoid malignancies affected cells of either T or B lineage, and not both [1]. Studies conducted with animal models of lymphoblastic leukemias and lymphomas revealed that malignant T and B cells, like their normal counterparts, have their origin in central lymphoid tissues. The thymus is essential in the genesis of a variety of murine lymphoid malignancies that are induced by oncogenic viruses, ionizing irradiation, carcinogenic hydrocarbons, and hormones, or that arise spontaneously in AKR mice (reviewed [2]). Removal of the thymus prevents these lymphoid malignancies, and thymus transplants restore susceptibility [2–4]. This is due to an initial transformation of thymocytes with sub-sequent seeding or metastasis to peripheral tissues. On the other hand, the bursa of Fabricius is the source of malignant B cells in avian lymphoid leukosis [5, 6].

This research was supported in part by Grants CA 16673 and CA 13148, awarded by the National Cancer Institute

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References

  1. Cooper MD, Peterson RDA, Garbrielsen AE, Good RA (1966) Lymphoid malignancy and development, differentiation, and function of the lymphoreticular system. Cancer Res 26: 1165–1169

    PubMed  CAS  Google Scholar 

  2. Miller JFAP (1961) Etiology and pathogenesis of mouse leukemia. Adv Cancer Res 6:291–368

    Article  PubMed  CAS  Google Scholar 

  3. McEndy DP, Boon MC, Furth J (1944) On the role of thymus, spleen and gonads in the development of leukemia in a high-leukemia stock of mice. Cancer Res 4:377–383

    Google Scholar 

  4. Kaplan HS (1959) Influence of thymectomy, splenectomy, and gonadectomy on incidence of radiation-induced lymphoid tumors in strain C57 black mice. J Natl Cancer Inst 11:83–90

    Google Scholar 

  5. Peterson RDA, Burmester BR, Frederickson, Purchase, HG, Good RA (1964) Effect of bursectomy and thymectomy on the development of visceral lymphomatosis in the chicken. J Natl Cancer Inst 32: 1343–1354

    PubMed  CAS  Google Scholar 

  6. Cooper MD, Payne LN, Dent PB, Burmester BR, Good RA (1968) Pathogenesis of avian lymphoid leukosis. I. Histogenesis. J Natl Cancer Inst 41:373–383

    CAS  Google Scholar 

  7. Burmester BR, Prickett CO, Belding TC (1946) A filtrable agent producing lymphoid tumors and osteoporosis in chickens. Cancer Res 6:189–196

    PubMed  CAS  Google Scholar 

  8. Vogt PK (1970) Envelope classification of avian RNA tumor viruses. In: Dutcher RM (ed). Comparative leukemia research. Bibl Haemat No 36 Karger Basel pp 153–167

    Google Scholar 

  9. Cooper MD, Purchase HG, Bockman DE, Gathings WE (1974) Studies on the nature of the abnormality of B cell differentiation in avian lymphoid leukosis: Production of heterogeneous IgM by tumor cells. J Immunol 113:1210–1222

    PubMed  CAS  Google Scholar 

  10. Hayward WS, Neel B, Astrin SM (1981) Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature 290:475–480

    Article  PubMed  CAS  Google Scholar 

  11. Cooper GM, Neiman PE (1981) Two distinct candidate transforming genes of lymphoid leukosis virus-induced neoplasms. Nature 292:857–858

    Article  PubMed  CAS  Google Scholar 

  12. McGrath MS, Pillemer E, Kooistra D, Weissman IL (1980) The role of MuLV receptors on T-lymphoma cells in lymphoma cell proliferation. Contemp Top Immunobiol 11:157–184

    PubMed  CAS  Google Scholar 

  13. Shimizu A, Takahashi N, Yaoita Y, Honjo T (1982) Organization of the constant-region gene family of the mouse immunoglobulin heavy chain. Cell 28:499–506

    Article  PubMed  CAS  Google Scholar 

  14. Hengartner H, Meo T, Muller E (1978) Assignment of genes for immunoglobulin χ and heavy chains to chromosomes 6 and 12 in mouse. Proc Natl Acad Sci USA 75:4494–4498

    Article  PubMed  CAS  Google Scholar 

  15. D’Eustachio P, Pravtcheva D, Marcu K, Ruddle FH (1980) Chromosomal location of the structural gene cluster encoding murine immunoglobulin heavy chains. J Exp Med 151:1545–1550

    Article  PubMed  Google Scholar 

  16. Swan D, D’Eustachio P, Leinwand L, Seidman J, Keithley D, Ruddle FH (1979) Chromosomal assignment of the mouse χ light chain genes. Proc Natl Acad Sci USA 76: 2735–2739

    Article  PubMed  CAS  Google Scholar 

  17. D’Eustachio P, Bothwell ALM, Takaro TK, Baltimore D, Ruddle FH (1981) Chromosomal location of structural genes encoding murine immunoglobulin λ light chains: Genetics of murine λ light chains. J Exp Med 153:793–800

    Article  PubMed  Google Scholar 

  18. Croce CM, Shander M, Martinis J, Cicurel L, D’Ancona GG, Dolby TW, Kaprowski H (1979) Chromosomal location of the genes for human immunoglobulin heavy chains. Proc Natl Acad Sci USA 76:3416–3419

    Article  PubMed  CAS  Google Scholar 

  19. Erikson J, Martinis J, Croce CM (1981) Assignment of the genes for human λ immunoglobulin chains to chromosome 22. Nature 294:173–175

    Article  PubMed  CAS  Google Scholar 

  20. Malcolm S, Barton P, Murphy C, Ferguson Smith MA, Bentley DL, Rabbits TH (1982) Localization of human immunoglobulin χ light chain variable region genes to the short arm of chromosome 2 by in situ hybridization. Proc Natl Acad Sci USA 79:4957–4961

    Article  PubMed  CAS  Google Scholar 

  21. Lenoir GM, Preud’homme JL, Berhein A, Berger R (1982) Correlation between immunoglobulin light chain expression and variant translocation in Burkitt’s lymphoma. Nature 298:474–476

    Article  PubMed  CAS  Google Scholar 

  22. Davis MM, Calame K, Erly PW, Livant DL, Joho R, Weissman IL, Hood L (1980) An immunoglobulin heavy-chain gene is formed by at least two recombinational events. Nature 283:733–739

    Article  PubMed  CAS  Google Scholar 

  23. Sakano H, Maki R, Kurosawa Y, Roeder W, Tonegawa S (1980) Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes. Nature 286:676–683

    Article  PubMed  CAS  Google Scholar 

  24. Cooper MD (1981) Pre-B cells: Normal and abnormal development. J Clin Immunol 1:81–89

    Article  PubMed  CAS  Google Scholar 

  25. Maki R, Kearney J, Paige C, Tonegawa S (1980) Immunoglobulin gene rearrangement in immature B cells. Science 209:1366–1369

    Article  PubMed  CAS  Google Scholar 

  26. Perry RR, Kelley DE, Coleclough C, Kearney JF (1981) Organization and expression of immunoglobulin genes in fetal liver hybridomas. Proc Natl Acad Sci USA 78:247–251

    Article  PubMed  CAS  Google Scholar 

  27. Alt F, Rosenberg N, Lewis S, Thomas E, Baltimore D (1981) Organization and reorganization of immunoglobulin genes in A-MuL V-transformed cells: Rearrangement of heavy but not light chain genes. Cell 27:381–390

    Article  PubMed  CAS  Google Scholar 

  28. Korsmeyer SJ, Hieter RA, Ravetch JV, Poplack DG, Waldmann TA, Leder P (1981) Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B cells. Proc Natl Acad Sci USA 78:7096–7100

    Article  PubMed  CAS  Google Scholar 

  29. Paige CJ, Kincade PW, Ralph P (1981) Independent control of immunoglobulin heavy and light chain expression in a murine pre-B cell line. Nature 292: 631–633

    Article  PubMed  CAS  Google Scholar 

  30. Cooper MD, Kearney JF, Gathings WE, Lawton AR (1980) Effects of anti-Ig anti bodies on the development and differentiation of B cells. Immunol Rev 52:29–53

    Article  PubMed  CAS  Google Scholar 

  31. Marcu KB, Cooper MD (1982) New views of the immunoglobulin heavy-chain switch. Nature 298:327–328

    Article  PubMed  CAS  Google Scholar 

  32. Berek C, Etlinger H, Julius M (eds) (1982) Idiotypes: Antigens on the Inside, Workshop at the Basel Institute for Immunology, November 19–20, 1981, F. Hoffman-La Roche & Co. Limited, Basel

    Google Scholar 

  33. Vogler LB, Crist WM, Bockman DE, Pearl ER, Lawton AR, Cooper MD (1978) Pre-B cell leukemia: A new phenotype of childhood lymphoblastic leukemia. N Engl J Med 298:872–878

    Article  PubMed  CAS  Google Scholar 

  34. Brouet JC, Preud’homme JL, Penit C, Valensi F, Rouget P, Seligmann M (1979) Acute lymphoblastic leukemia with pre-B cell characteristics. Blood 54:269–273

    PubMed  CAS  Google Scholar 

  35. Vogler LB, Preud’homme JL, Seligmann M, Gathings WE, Crist WM, Cooper MD, Bollum FJ (1981) Diversity of immunoglobulin expression in leukaemic cells resembling B-lymphocyte precursors. Nature 290:339–341

    Article  PubMed  CAS  Google Scholar 

  36. Greaves M, Verbi W, Vogler L, Cooper M, Ellis R, Ganeshagura K, Hoffbrand V, Janossy G, Bollum FJ (1979) Antigenic and enzymatic phenotypes of the pre-B subclass of acute lymphoblastic leukaemia. Leukemia Res 3:353–362

    Article  CAS  Google Scholar 

  37. Balch CM, Dougherty PA, Vogler LB, Ades EW, Ferrone S (1979) A new B cell differentiation antigen (BDA) on normal and leukemic human B lymphocytes that is distinct from known DR (Ia-like) antigens. J Immunol 121:2322–2328

    Google Scholar 

  38. Abramson CS, Kersey JH, LeBien TW (1981) A monoclonal antibody (BA-1) reactive with cells of human B lymphocyte lineage. J Immunol 126: 83–88

    PubMed  CAS  Google Scholar 

  39. Nadler LM, Ritz J, Hardy R, Pesando JM, Schlossman SF (1981) A unique cell surface antigen identifying lymphoid malignancies of B cell origin. J Clin Invest 67: 134–140

    Article  PubMed  CAS  Google Scholar 

  40. Pullen DJ, Crist WM, Falletta JM, Boyett JM, Roper MA, Dowell B, van Eys J, Humphrey GB, Head D, Brock BL, Black-stock R, Metzgar RS, Cooper MD (to be published) ALinC 13 classification protocol for acute lymphocytic leukemia: Characterization of immunologic phenotypes and correlation with treatment results. In: Proceedings of the St. Jude Leukemia Symposium

    Google Scholar 

  41. Fialkow PJ, Jacobson RJ, Papayannopoulou T (1977) Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am J Med 63:125–130

    Article  PubMed  CAS  Google Scholar 

  42. Fialkow PJ, Denman AM, Jacobson RJ, Lowenthal MN (1978) Chronic myelocytic leukemia: Origin of some lymphocytes from leukemic stem cells. J Clin Invest 62:815–823

    Article  PubMed  CAS  Google Scholar 

  43. Vogler LB, Crist WM, Vinson PC, Sarrif A, Brattain MG, Coleman MS (1979) Philadelphia-chromosome-positive pre-B cell leukemia presenting as blast crisis of chronic myelogenous leukemia. Blood 54:1164–1169

    PubMed  CAS  Google Scholar 

  44. Greaves MF, Verbi W, Reeves BR, Hoffbrand AV, Drysdale HC, Jones L, Sacker LS, Samaratunga I (1979) “Pre-B” phenotypes in blast crisis of Ph1 positive CML: Evidence for a pluripotential stem cell “target”. Leukemia Res 3:181–191

    Article  CAS  Google Scholar 

  45. LeBien TW, Hozier J, Minowada J, Kersey JH (1979) Origin of chronic myelocytic leukemia in a precursor of pre-B lymphocytes. N Engl J Med 301: 144–147

    Article  PubMed  CAS  Google Scholar 

  46. Burrows PD, LeJeune M, Kearney JF (1979) Evidence that mouse pre-B cells synthesise μ heavy chains but no light chains. Nature 280:838–841

    Article  PubMed  CAS  Google Scholar 

  47. Levitt D, Cooper MD (1980) Mouse pre-B cells synthesize and secrete μ heavy chains but not light chains. Cell 19:617–625

    Article  PubMed  CAS  Google Scholar 

  48. Gathings WE, Mage RG, Cooper MD, Young-Cooper GO (1982) A subpopulation of small pre-B cells in rabbit bone marrow expresses light chains and exhibits allelic exclusion of b locus allotype. Eur J Immunol 12:76–81

    Article  PubMed  CAS  Google Scholar 

  49. Kamps WA, Cooper MD (1982) Microenvironmental studies of pre-B and B cell development in human and mouse fetuses. J Immunol 129:526–531

    PubMed  CAS  Google Scholar 

  50. Kubagawa H, Gathings WE, Levitt D, Kearney JF, Cooper MD (1982) Immunoglobulin isotype expression of normal pre-B cells as determined by immunofluorescence. J Clin Immunol 2:264–269

    Article  PubMed  CAS  Google Scholar 

  51. Kubagawa H, Mayumi M, Crist WM, Cooper MD (to be published) Immunoglobulin heavy chain switching in pre-B leukemias. Nature

    Google Scholar 

  52. Ravetch JV, Siebenlist U, Korsmeyer S, Waldmann T, Leder P (1981) Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes. Cell 27:583–591

    CAS  Google Scholar 

  53. Ellison J, Hood L (1982) Linkage and sequence homology of two human immunoglobulin γ heavy chain constant region genes. Proc Natl Acad Sci USA 79:1984–1988

    Article  PubMed  CAS  Google Scholar 

  54. Takahaskhi N, Ueda S, Obata M, Nikaido T, Nakai S, Honjo T (1982) Structure of human immunoglobulin gamma genes: Implications for evolution of a gene family. Cell 29:671–679

    Article  Google Scholar 

  55. Max EE, Battey J, Ney R, Kirsch IR, Leder P (1982) Duplication and deletion in the human immunoglobulin ε genes. Cell 29:691–699

    Article  PubMed  CAS  Google Scholar 

  56. Alt FW, Rosenberg N, Casanova RJ, Thomas E, Baltimore D (1982) Immunoglobulin heavy-chain expression and class switching in a murine leukemia cell line. Nature 296:325–331

    Article  PubMed  CAS  Google Scholar 

  57. Yaoita Y, Kumagai Y, Okumura K, Honjo T (1982) Expression of lymphocyte surface IgE does not require switch recombination. Nature 297:697–699

    Article  PubMed  CAS  Google Scholar 

  58. Alt FW, Enea V, Bothwell ALM, Baltimore D (1980) Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain. Cell 21:1–12

    Article  PubMed  CAS  Google Scholar 

  59. Hieter PA, Korsmeyer SJ, Waldmann TA, Leder P (1981) Human immunoglobulin χ light chain genes are deleted or rearranged in λ-producing B cells. Nature 290:368–372

    Article  PubMed  CAS  Google Scholar 

  60. Coleclough C, Perry RP, Karjalainen K, Weigert M (1981) Aberrant rearrangments contribute significantly to the allelic exclusion of immunoglobulin gene expression. Nature 290:371–378

    Article  Google Scholar 

  61. Godal T, Funderud S (1982) Human B cell neoplasms in relation to normal B cell differentiation and maturation processes. Adv Cancer Res 36:211–255

    Article  PubMed  CAS  Google Scholar 

  62. Fu SM, Chiorazzi N, Kunkel HG, Halper JP, Harris SR (1978) Induction of in vitro differentiation and immunoglobulin synthesis of human leukemic B lymphocytes. J Exp Med 148:1570–1578

    Article  PubMed  CAS  Google Scholar 

  63. Robert KH (1979) Induction of monoclonal antibody synthesis in malignant human B cells by polyclonal B cell activators: Relationship between B cell subsets and prognosis. Immunol Rev 48:123–143

    Article  PubMed  CAS  Google Scholar 

  64. Saiki O, Kishimoto T, Kuritani T, Muraguchi A, Yamamura Y (1980) In vitro induction of IgM secretion and switching to IgG production in human B leukemic cells with the help of T cells. J Immunol 124:2609–2614

    PubMed  CAS  Google Scholar 

  65. Kubagawa H, Mayumi M, Gathings WE, Kearney JF, Cooper MD (to be published) Extent of clonal involvement in B cell malignancies. In: Murphy S, Gilbert J (eds) Leukemia research: Advances in cell biology and treatment. Elsevier/North-Holland, New York

    Google Scholar 

  66. Mayumi M, Kubagawa H, Omura GA, Gathings WE, Kearney JF, Cooper MD (1982) Studies on the clonal origin of human B cell leukemia using monoclonal anti-idio-type antibodies. J Immunol 129:904–910

    PubMed  CAS  Google Scholar 

  67. Kubagawa H, Mayumi M, Kearney JF, Cooper MD (1982) Immunoglobulin V H determinants defined by monoclonal antibodies. J Exp Med 156: 1010–1024

    Article  PubMed  CAS  Google Scholar 

  68. Klein G (1981) The role of gene dosage and genetic transposition in carcinogenesis. Nature 294:313–318

    Article  PubMed  CAS  Google Scholar 

  69. Kubagawa H, Vogler LB, Capra JD, Conrad ME, Lawton, Cooper MD (1979) Studies on the clonal origin of multiple myeloma: Use of individually specific (idiotype) antibodies to trace the oncogenic event to its earliest point of expression in B cell differentiation. J Exp Med 150:792–807

    Article  PubMed  CAS  Google Scholar 

  70. Mackay IR, Toh BH, Pederson JS (1981) Autoantibodies to cytoskeletal filaments, actin and intermediate filaments, segregate with different types of chronic hepatitis. In: The Walter and Eliza Hall Institute of Medical Research. Annual Review 1980–81, pp 96–97

    Google Scholar 

  71. Dellagi K, Brouet JC, Perreau J, Paulin D (1982) Human monoclonal IgM with autoantibody activity against intermediate filaments. Proc Natl Acad Sci USA 79:446–450

    Article  PubMed  CAS  Google Scholar 

  72. Lane M, Sainten A, Cooper GM (1982) Stage-specific transforming genes of human and mouse Band T lymphocyte neoplasms. Cell 28:873–880

    Article  PubMed  CAS  Google Scholar 

  73. Lynch KRG, Rohrer JW, Odermatt B, Gebel HM, Autry JR, Hoover RG (1979) Immunoregulation of murine myeloma cell growth and differentiation: A monoclonal model of B cell differentiation. Immunol Rev 48:45–80

    Article  PubMed  CAS  Google Scholar 

  74. Abbas AK (1979) Antigen and T lymphocyte mediated suppression of myesoma cells: Model systems for regulation of lymphocyte function. Immunol Rev 48:245–264

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. M. D. Cooper
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  2. H. Kubagawa
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Editors and Affiliations

  1. Medizinische Klinik, Abteilung fuer klinische Chemie, Universitaets-Krankenhaus Eppendorf, Martinistraße 52, 2000, Hamburg 20, Federal Republic of Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, 20014, Bethesda, MD, USA

    Robert C. Gallo

  3. Imperial Cancer Research Fund Laboratories, P.O. Box 123, WC2 A3PK, London, Great Britain

    Melvyn F. Greaves

  4. Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA

    Malcolm A. S. Moore

  5. Abteilung fuer Haematologie und Onkologie, Universitaets-Kinderklinik, Martinistraße 52, 2000, Hamburg 20, Federal Republic of Germany

    Kurt Winkler

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Cooper, M.D., Kubagawa, H. (1983). B-Cell Malignancies: Origin and Extent of Clonal Involvement. In: Neth, R., Gallo, R.C., Greaves, M.F., Moore, M.A.S., Winkler, K. (eds) Modern Trends in Human Leukemia V. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68761-7_83

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  • DOI: https://doi.org/10.1007/978-3-642-68761-7_83

  • Publisher Name: Springer, Berlin, Heidelberg

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