Abstract
Culture of mouse myeloid leukemic cells in the presence of a variety of chemical substances can induce the differentiation of some at least of these cells to maturing granulocytes and macrophages, Essentially similar events occur with the human myeloid leukemia line HL60 [1].
This work was supported by the Carden Fellowship Fund of the Anti-Cancer Council of Victoria, The National Health and Medical Research Council, Canberra, and the National Institutes of Health. Grant Nos. CA-22556 and CA-25972
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abraham J, Rovera G (1981) Inducers and inhibitors of leukemic cell differentiation in vitro. In: Baserga R (ed) Tissue growth factors. Springer, Berlin Heidelberg New York, pp 405–425
Burgess A W, Metcalf D (1980) Characterization of a serum factor stimulating the differentiation of myelomonocytic leukemic cells. Int J Cancer 26:647–654
Falk A, Sachs L (1980) Clonal regulation of the induction of macrophage- and granulocyte-inducing proteins for normal and leukemic myeloid cells. Int J Cancer 26: 595–601
Hayashi M, Okabe J, Hozumi M (1979) Sensitization of resistant myeloid leukemia clone cells by anticancer drugs to factor-stimulating differentiation. Gan 70:235–238
Ichikawa Y (1970) Further studies on the differentiation of a cell line of myeloid leukemia. J Cell Physiol 76: 175–184
Liebermann D, Hoffman-Liebermann B, Sachs L (1982) Regulation and role of different macrophage- and granulocyte-inducing proteins in normal and leukemic myeloid cells. Int J Cancer 29: 159–161
Lotem J, Lipton JH, Sachs L (1980) Separation of different molecular forms of macrophage and granulocyte-inducing protein for normal and myeloid leukemic myeloid cells. Int J Cancer 25: 763–771
Metcalf D (1979) Clonal analysis of the action of GM-CSF on the proliferation and differentiation of myelomonocytic leukemic cells. Int J Cancer 24: 616–623
Metcalf D (1980) Clonal extinction of myelomonocytic leukemic cells by serum from mice injected with endotoxin. Int J Cancer 25:225–233
Metcalf D (1981) Induction of differentiation in murine myelomonocytic leukemic cells by the serum of patients with acute myeloid leukemia and other diseases. Int J Cancer 27:577–584
Metcalf D (1982) Sources and biology of regulatory factors active on mouse myeloid leukemic cells. J Cell Physiol [Suppl] 1: 175
Metcalf D (1982) Regulatory control of the proliferation and differentiation of normal and leukemia cells. Natl Cancer Inst Monogr 60: 123–131
Metcalf D (1982) Regulator-induced suppression of myelomonocytic leukemic cells: clonal analysis of early cellular events. Int J Cancer 30:203–210
Metcalf D, Moore MAS (1970) Factors modifying stem cell proliferation of myelomonocytic leukemic cells in vitro and in vivo. J N C I 44:801–808
Nicola NA, Metcalf D (1981) Biochemical properties of differentiation factors for murine myelomonocytic leukemic cells in organ conditioned media: separation from colony-stimulating factors. J Cell Physiol 109:253–264
Okabe J, Honma Y, Hozumi M (1977) Inhibition of RNA and protein synthesis makes non-differentiating mouse myeloid leukemia cells sensitive to a factor(s) stimulating differentiation. Int J Cancer 20:933–940
Ruscetti FW, Collins SJ, Woods AM, Gallo RC (1981) Clonal analysis of the response of human myeloid leukemic cell lines to colony-stimulating activity. Blood 58:285–292
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Metcalf, D. (1983). Early Events in the Suppression of Myeloid Leukemic Cells by Biological Regulators. In: Neth, R., Gallo, R.C., Greaves, M.F., Moore, M.A.S., Winkler, K. (eds) Modern Trends in Human Leukemia V. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68761-7_62
Download citation
DOI: https://doi.org/10.1007/978-3-642-68761-7_62
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-11858-9
Online ISBN: 978-3-642-68761-7
eBook Packages: Springer Book Archive