Abstract
Alzheimer’s disease (AD) may be defined clinicopathologically as a progressive presenile dementing organic brain disease, starting insidiously between 40 and 65 years of age. The dominant psychiatric symptoms are amnesia, apraxia, agnosia, and aphasia, the most prominent pathoanatomical correlate of which is cerebral atrophy with striking histological changes such as senile plaques and neurofibrillary degeneration.
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Brun, A. (1982). Alzheimer’s Disease and its Clinical Implications. In: Platt, D. (eds) Geriatrics 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68214-8_16
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