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Inhibition of Hematopoietic Cell Proliferation

  • Chapter
Tissue Growth Factors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 57))

Abstract

In healthy post-natal human beings, hematopoiesis is restricted to the bone marrow. As mature blood cells are utilized or die in the periphery, they are continuously replenished by the bone marrow. For years, it has been recognized that blood cell renewal is accomplished by maturation of morphologically identifiable precursors (blast cells) in the bone marrow. More recently, with the development of hematopoietic cell culture techniques, the concept has evolved that these morphologically recognizable precursor cells are in turn replenished from hematopoietic stem cells. In this hierarchical scheme of hematopoiesis, hematopoietic stem cells have the dual capacities of self-renewal and differentiation; that is, they are capable both of maintaining their own numbers and of giving rise to progeny committed to a single line of differentiation. A model of hematopoiesis based on this scheme is depicted in Fig. 1.

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Authors and Affiliations

  1. Department of Medicine, Center for the Health Sciences, University of California, Los Angeles, USA

    M. J. Cline

  2. Wadsworth Veterans Administration Hospital, Los Angeles, USA

    M. J. Cline

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  1. J. H. Fitchen
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  2. M. J. Cline
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Editors and Affiliations

  1. Fels Research Institute and Department of Pathology, Temple University School of Medicine, Health Sciences Center, Philadelphia, PA, 19140, USA

    Renato Baserga M.D. (Senior Investigator) (Senior Investigator)

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Fitchen, J.H., Cline, M.J. (1981). Inhibition of Hematopoietic Cell Proliferation. In: Baserga, R. (eds) Tissue Growth Factors. Handbook of Experimental Pharmacology, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67986-5_13

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  • DOI: https://doi.org/10.1007/978-3-642-67986-5_13

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