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Biosynthesis of 16-Membered Macrolide Antibiotics

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Biosynthesis

Part of the book series: Antibiotics ((ANTIBIOTICS,volume 4))

Abstract

To date 57 components of the structurally known 16-membered macrolide antibiotics have been identified (Ōmura and Nakagawa, 1975; Morin and Gorman, 1967; Celmer, 1971; Mallams, 1978). Some of the macrolide antibiotics, including leucomycin, spiramycin, and acetylspiramycin have clinical applications and/or are used as supplements in animal feeds. The currently known macrolides can be classified biosynthetically into four groups, on the basis of the pattern of glycosidation of each sugar to the aglycone moiety, the varieties of constituent sugar, and the carbon skeleton of the aglycones (Ōmura and Takeshima, 1977) (Fig. 1). The first group is represented by the clinically important antibiotics magnamycin and leucomycin. The characteristic features of the antibiotics belonging to this group are the acyl group at the 3-position on the lactone ring, the acyl group at the 4″-position of the mycarose moiety, the structure of the 9–13 positions in the lactone ring, and their combinations.The total number of such macrolides has reached 36.

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Authors
  1. Satoshi Ōmura
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  2. Akira Nakagawa
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Editors and Affiliations

  1. Department of Biochemistry The Medical and Dental Schools, Northwestern University, Chicago, IL, 60611, USA

    John W. Corcoran Ph.D.

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Ōmura, S., Nakagawa, A. (1981). Biosynthesis of 16-Membered Macrolide Antibiotics. In: Corcoran, J.W. (eds) Biosynthesis. Antibiotics, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67724-3_8

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  • DOI: https://doi.org/10.1007/978-3-642-67724-3_8

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