Abstract
Any proposed model for the active site structure and the mechanism of action of carbonic anhydrase should take into account those experimental data which are more directly related to the metal ion environment. In particular, water proton relaxation measurements of solutions of carbonic anhydrase derivatives containing paramagnetic metal ions constitute one of the most reliable insights into the solvation of the metal itself and the possible hydrogen ion equilibria involved (Fabry et al., 1970).
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References
Bazzi D, Bertini I, Luchinat C, Scozzafava A (1979) The electronic spectra of cobalt (II) bovine carbonic anhydrase. Inorg Chim Acta 36: L431–432
Bertini I, Canti G, Luchinat C, Scozzafava A (1978a) Characterization of cobalt ( II) bovine carbonic anhydrase and of its derivatives. J Am Chem Soc 100: 4873–4877
Bertini I, Borghi E, Luchinat C (1978b) Characterization of nickel (II) bovine carbonic anhydrase and its inhibitor derivatives. Bioinorg Chem 9: 495 —504
Bertini I, Luchinat C, Scozzafava A (1978c) Binding affinity of bicarboxylate ions for cobalt ( II) bovine carbonic anhydrase. Bioinorg Chem 9: 93–100
Bertini I, Canti G, Luchinat C, Scozzafava A (1979) Characterization of oxovanadium ( IV) substituted bovine carbonic anhydrase B. Inorg Chini Acta 36: 9–12
Fabry (Riepe) ME, Koenig SH, Shillinger WE (1970) Nuclear magnetic relaxation dispersion in protein solutions. IV. Proton relaxation at the active site of carbonic anhydrase. J Biol Chem 245: 4256–4262
Karman KK, Petef M, Fridborg K, Cid-Dresdner H, Lövgren S (1977) Structure and function of carbonic anhydrases. FEBS Lett 73: 115–119
Pesando JM (1975) Proton magnetic resonance studies of carbonic anhydrase. II. Group controlling catalytic activity. Biochemistry 14: 681–688
Whitney PL, Brandt H (1976) Effects of two ionizing groups on the active site of human carbonic anhydrase B. J Biol Chem 251: 3862–386
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© 1980 Springer-Verlag Berlin Heidelberg
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Bertini, I., Luchinat, C., Scozzafava, A. (1980). Some Structural Aspects of Carbonic Anhydrase. In: Bauer, C., Gros, G., Bartels, H. (eds) Biophysics and Physiology of Carbon Dioxide. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67572-0_16
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DOI: https://doi.org/10.1007/978-3-642-67572-0_16
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