Abstract
The activities of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (AldDH) soluble and mitochondrial have been determined in liver of chronic ethanol fed rats. Experimental intoxication was obtained in male Wistar rats by administration of 20% ethanol solution as the only drinking fluid for 3 months. The effect of simultaneous administration of fat diet (48% vegetable fat of total calories) and acetaldehyde (added in a 1.5% to ethanol solution) was also carried out. The results obtained show that ADH and soluble AldDH are not significantly affected by chronic administration of ethanol and/or acetaldehyde. However these two soluble enzymes were significantly decreased by the fat diet. Ethanol markedly decreased mitochondrial AldDH activity, and fat diet did not produce any significant change. Acetaldehyde simultaneously administered to ethanol produced only slight changes either in soluble ADH and AldDH as in the mitochondrial AldDH.
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© 1979 Springer-Verlag
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Cascales, M., Cerdán, S., Santos-Ruiz, M.R., Feijóo, B., Santos-Ruiz, A. (1979). Alcohol and Aldehyde Dehydrogenase on Chronic Ethanol Intoxication. In: Chambers, P.L., Günzel, P. (eds) Mechanism of Toxic Action on Some Target Organs. Archives of Toxicology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67265-1_63
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DOI: https://doi.org/10.1007/978-3-642-67265-1_63
Publisher Name: Springer, Berlin, Heidelberg
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