Abstract
Only a few years ago, the clinicians were still impressed by a decrease of digitalis tolerance in uremic patients with respect to the daily dose required for induction of over dosage symptoms (Jelliffe 1967, 1968; Christiansen et al., 1973; Jelliffe and Brooker, 1974; Dettli, 1971; Ohnhaus et al., 1974; Kramer, 1974). By the introduction of serial radioimmunologic determinations of the plasma digoxin, we have learned to look at digitalis tolerance from a different aspect, which nowadays may be related to the plasma concentration. During the last years, we had accumulated some evidence (Buckesfeld and Bolte 1974; Kramer, 1977) that digitalis tolerance is in fact increased in uremic patients in relation to the plasma concentration. In order to substantiate these preliminary observations, a prospective study was undertaken to determine the incidence of digitalis toxicity in patients with an elevated plasma digoxin in relation to the plasma creatinine.
Supported by the Deutsche Forschungsgemeinschaft im Rahmen des SFB 89, Kardiologie, Göttingen.
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Kramer, P., Stroh, E., Matthei, D., Teiwes, F., Scheler, F. (1978). Increased Digitalis Tolerance in Uremic Patients. In: Bodem, G., Dengler, H.J. (eds) Cardiac Glycosides. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66904-0_26
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DOI: https://doi.org/10.1007/978-3-642-66904-0_26
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