Abstract
More than any other tool available, the analysis of the Bryan high-titer strain of Rous sarcoma virus has contributed to the beginning of molecular-biologic investigation of the RNA tumor viruses. Successive steps in research with this strain extended from 1964, with the biologic description of its defectiveness (Hanafusa et al., 1964), to 1969, when it was first used to define the existence in the host cell of endogenous avian RNA tumor virus genes (Weiss, 1969), to 1971, when the lack of the viral glycoproteins was first directly demonstrated (Scheele and Hanafusa, 1971), and to 1974, when a deletion was recognized in the viral genome RNA (Duesberg et al., 1975). Since most strains of avian sarcoma virus, even those derived from Rous isolates, are nondefective viruses, replicating without a helper virus, it seems most probable that the Bryan high-titer strain is a spontaneous-deletion mutant. Its existence has been of great advantage for all virologie investigations of RNA tumor viruses; as a mutant applied to the study of the questions referred to above, its use predated by almost ten years the experiments with temperature-sensitive mutants of avian sarcoma viruses, which are the subject of this review.
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Friis, R.R. (1978). Temperature-Sensitive Mutants of Avian RNA Tumor Viruses: A Review. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 79. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66853-1_6
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