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Toxic Effects of Lead, with Particular Reference to Porphyrin and Heme Metabolism

  • Chapter
Heme and Hemoproteins

Abstract

Lead has been shown to interfere with the biosynthesis of heme in a number of in vitro systems and in experimental animals as well as in human beings. Several steps of the heme biosynthetic chain are subject to the toxic effects of lead. ALA-dehydratase and ferrochelatase, in particular, are two enzymes which are strongly inhibited by lead, leading to decreased heme synthesis.

Supported by a USPHS grant ES01055 and an ACS grant BC 180.

Recipient of a Career Scientist Award (I–768) of the Health Research Council of the City of New York.

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Authors
  1. Shigeru Sassa
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  1. Medical Research Council Labs., MRC Toxicology Unit, Woodmansterne Road, SM5 4EF, Carshalton, Surrey, Great Britain

    Francesco De Matteis  & W. Norman Aldridge  & 

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Sassa, S. (1978). Toxic Effects of Lead, with Particular Reference to Porphyrin and Heme Metabolism. In: De Matteis, F., Aldridge, W.N. (eds) Heme and Hemoproteins. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 44. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66763-3_11

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  • DOI: https://doi.org/10.1007/978-3-642-66763-3_11

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