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Phase Transitions, Protein Aggregation and a New Method for Modulating Membrane Fluidity

  • Conference paper
Biochemistry of Membrane Transport

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

It is well known that hydrated phospholipids can undergo a thermotropic phase transition in which the hydrocarbon chains change from a relatively rigid and ordered arrangement to a phase in which they are fluid and disordered. In the rigid, so-called crystal phase, the lateral diffusion of lipids in the bilayer is restricted compared with diffusion rates in the fluid, liquid-crystal conformation. The temperature (Tc) at which lipids undergo a phase change and the dependence of this temperature on hydrocarbon chain length, unsaturation, polar group, and metal ion interactions have been documented for many lipid systems (Chapman, 1975). In mixed lipid dispersions the phase transition may involve a cocrystallisation of the constituent lipids or conversely their segregation within the lamellar plane giving rise to broad melting endotherms or a number of individual, relatively narrow endotherms, respectively. The phase diagrams of several mixed lipid systems have been established (Ladbrooke and Chapman, 1969; Phillips et al., 1970; Shimshick and McConnell, 1973), particularly those of binary phospholipid-cholesterol mixtures (Ladbrooke et al., 1968).

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Authors
  1. D. Chapman
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  2. B. A. Cornell
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  3. P. J. Quinn
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Editor information

Editors and Affiliations

  1. Laboratorium für Biochemie, Eidgenössische Technische Hochschule Zürich, 8006, Zürich, Switzerland

    Giorgio Semenza  & Ernesto Carafoli  & 

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Chapman, D., Cornell, B.A., Quinn, P.J. (1977). Phase Transitions, Protein Aggregation and a New Method for Modulating Membrane Fluidity. In: Semenza, G., Carafoli, E. (eds) Biochemistry of Membrane Transport. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66564-6_5

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  • DOI: https://doi.org/10.1007/978-3-642-66564-6_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66566-0

  • Online ISBN: 978-3-642-66564-6

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