Abstract
The maximum period of total ischemia that the brain can endure without irreversible damage remains ill-defined. Clinical observations, as well as a number of experimental results, indicate that cellular damage occurs if the period of ischemia is longer than 5–7 min (1,2,3,4). However, as recovery of neuronal function has been reported to occur following ischemia of considerably longer duration, using models that either remove blood from the brain (5) or prevent its stagnation during ischemia (6), it has been assumed that survival of brain cells is partly limited by failure of recirculation of the tissue after the termination of the ischemia.
This Study was supported by grantsn from the Swedish Medical Research Council (Projects No. 14X-263 and 14X-2179), from the Swedish Bank Tercentuary Fund and from U.S. PHS Grant No. 5 RO1 NS 07838-05 from NHI.
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Brierley, J.B., Ljunggren, B., Siesjö, B.K. (1975). Neuropathological Alterations in Rat Brain after Complete Ischemia Due to Raised Intracranial Pressure. In: Lundberg, N., Pontén, U., Brock, M. (eds) Intracranial Pressure II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66086-3_35
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DOI: https://doi.org/10.1007/978-3-642-66086-3_35
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