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Die Chemie des Insulins

  • Chapter
Diabetes mellitus · A

Part of the book series: Handbuch der inneren Medizin ((INNEREN 7,volume 7 / 2 / A))

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Zusammenfassung

Insulin wird in den β-Zellen der Langerhansschen Inseln des Pankreas synthetisiert und gespeichert. Die Synthese verläuft über folgende Stufen: Die einkettige Vorstufe zum Proinsulin wird in den Ribosomen im endoplasmatischen Reticulum synthetisiert. Die Synthese beginnt mit dem N-terminalen Phenylalanin der B-Kette, setzt sich mit der B-Kette, dem Verknüpfungspeptid und der A-Kette fort, um mit dem C-terminalen Asparagin der A-Kette abzuschließen.

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  1. J. Schlichtkrull
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  2. H. Ege
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  3. K. H. Jørgensen
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  4. J. Markussen
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  5. F. Sundby
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    Karl Oberdisse

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Schlichtkrull, J., Ege, H., Jørgensen, K.H., Markussen, J., Sundby, F. (1975). Die Chemie des Insulins. In: Cerasi, E., et al. Diabetes mellitus · A. Handbuch der inneren Medizin, vol 7 / 2 / A. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66033-7_3

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